The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical results for point mutations and small insertions/deletions from 3,281 tumours
a consequence of MSK1/2 activity, induces chromatin remodeling at target gene regulatory elements, thereby promoting gene expression. Transcription factors, including RELA of NF-κB and CREB, experience phosphorylation by MSK1/2, thereby positively influencing gene expression. MSK1/2, responding to si...
The heme oxygenase system includes HO and biliverdin reductase, as well as products of heme degradation: CO, iron,biliverdin, andbilirubin. The catabolism of heme, especially of hemoglobin of senescent or damaged erythrocytes in the spleen by macrophages. leads to the formation of equimolar amount...
Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation
Small non-coding RNAs (ncRNAs) are important regulators of gene expression in eukaryotes. Previously, only microRNAs (miRNAs) and piRNAs have been identified in the silkworm, Bombyx mori. Furthermore, only ncRNAs (50-500nt) of intermediate size have been
Tumor invasiveness reflects many biological changes associated with tumorigenesis, progression, metastasis, and drug resistance. Therefore, we performed a systematic assessment of invasiveness-related molecular features across multiple human cancers. Mul
"There are so many different ways to mess up the packaging of DNA that the mutations look random in any one tumor type, but now we have enough data to see that chromatin remodeling is a big factor in a lot of these tumors," Stuart said. Stuart played a central role in creating the ...
PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer research. This class of short non-coding RNAs (ncRNA) has roles in genomic stability, chromatin remodeling, messenger RNA (mRNA) integrity, and genome structure. We summarized the mechanisms underlying th...
et al. ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer. Nat. Commun. 13, 2282 (2022). Article ADS CAS PubMed PubMed Central Google Scholar Couturier, C. P. et al. Single-cell RNA-seq reveals that glioblastoma ...
Analysis of single-nucleus RNA-seq of glaucoma-relevant eye tissues reveals that the POAG and IOP colocalizing genes and genome-wide associations are enriched in specific cell types in the aqueous outflow pathways, retina, optic nerve head, peripapillary sclera, and choroid. This study nominates ...