Chromatin structureDNA loopEnvironmentGene expressionHistone modificationNucleosome remodelingStem cellTranscription regulationChromatin by its nature presents a major obstacle to all processes occurring in the nucleus: transcription, DNA repair, and replication. At local level, intimate interactions of DNA with...
Chromatin structure and gene expression This book provides an up-to-date review of DNA packaging into chromatin and consequences for gene expression. It is aimed at researchers in the areas of DN... Elgin,CR Sarah - IRL Press, 被引量: 538发表: 0年 Chromatin Structure and Gene Activity: Th...
DNA methylationis also relevant in determining chromatin structure[42,43]and regulating gene expression[44]. Changes in methylation are typical for cancer cells, but similar changes have been observed also in senescent cells[45–47]. Aging cells exhibit global hypomethylation and local hypermethylation...
Acquisition of cell fate is thought to rely on the specific interaction of remote cis-regulatory modules (CRMs), for example, enhancers and target promoters. However, the precise interplay between chromatin structure and gene expression is still unclear,
Chromatin structure and gene expression. Proc. Natl Acad. Sci. USA 93, 9384–9388 (1996). Article CAS PubMed PubMed Central Google Scholar John, S. et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat. Genet. 43, 264–268 (2011). This is the first ...
How is gene expression regulated at the chromatin structure level?Question:How is gene expression regulated at the chromatin structure level?Gene Regulation:In genetics, the phrases gene regulation denotes the phenomena wherein the activity of a particular gene is activated or suppressed. The act...
Having established that HPV integration results in changes in chromatin structure and dysregulated gene expression in cancer cell lines and patient tumors, we asked whether outlier expressed genes could play a driving role in tumorigenesis. We investigated the transcriptome of HPV+ HNSC and CESC tumors...
In this review, we will discuss our current understanding of the mechanisms by which each of these types of insulators affect chromatin structure and gene expression. We will distinguish between the two types by using the “enhancer-blocking” or “barrier” nomenclature proposed by Gaszner and ...
This region might control the constitutive over-expression of cathepsin D in hormone-independent breast cancer cells. All together, these data demonstrate that a local reorganization of the chromatin structure over pS2 and cathepsin D promoters accompanies the establishment of the hormone-independent ...
The relationship between chromatin organization and gene regulation remains unclear. While disruption of chromatin domains and domain boundaries can lead to misexpression of developmental genes, acute depletion of regulators of genome organization has a