This novel eukaryotic gene, masc1, encodes a protein that has all motifs of the catalytic domain of eukaryotic C5-DNA-methyltransferases but is unique in that it lacks a regulatory N-terminal domain. The disruption of masc1 has no effect on viability or methylation maintenance but prevents the...
The relationship between chromatin organization and gene regulation remains unclear. While disruption of chromatin domains and domain boundaries can lead to misexpression of developmental genes, acute depletion of regulators of genome organization has a relatively small effect on gene expression. It is ther...
Prenatal nutrition and the risk of adult obesity: Long-term effects of nutrition on epigenetic mechanisms regulating gene expression chromatin GlcNAcylation, depend on the energetic state of the cell, making GlcNAcylation a functional link between nutrition and regulation of gene expression... E Navarro...
Core promoter T-blocks correlate with gene expression levels in. C. elegans. Genome Res. 21, 707–717 (2011). Article CAS PubMed Google Scholar Raveh-Sadka, T. et al. Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast. Nat. Genet. 44, ...
Looping, linking, and chromatin activity: new insights into beta-globin locus regulation Cell (2000) D.I. Martin et al. Regulation of beta-globin gene expression: straightening out the locus Curr. Opin. Genet. Dev. (1996) S. Chambeyron et al. Does looping and clustering in the nucleus re...
While many know that serotonin impacts mood and emotions, a smattering of studies have found that this neurotransmitter can modify histones and regulate gene expression. Now, fascinating new research reveals that histone serotonylation contributes to the regulation of aggressive brain tumors, playing a...
Chromatin Remodeling Complex Interacts with ADD1/SREBP1c To Mediate Insulin-Dependent Regulation of Gene Expression. Han D, Lee HW, Seong RH, Kim JB: Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. ... Yun,Sok,Lee,... - ...
Helper T cell differentiation involves silencing as well as activation of gene expression. We have identified a conserved silencer of the gene encoding interleukin 4 (Il4) marked by DNase I hypersensitivity (HS IV) and permissive chromatin structure in all helper T cells. Deletion of HS IV incre...
of nuclear space. Besides this role, chromatin carries much of the epigenetic information which modulates genome activity including regulation of gene expression. Indeed, the chromatin structure is highly dynamic and affects all processes operating on DNA such as DNA repair, replication or transcription...
Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of ...