The relationship between chromatin organization and gene regulation remains unclear. While disruption of chromatin domains and domain boundaries can lead to misexpression of developmental genes, acute depletion of regulators of genome organization has a relatively small effect on gene expression. It is ther...
Turner, B. M. (2002). Chromatin and Gene Regulation: Mechanisms in Epigenetics, Blackwell Science, Oxford.Turner, B.M. (2001). Chromatin and Gene Regulation (Oxford, UK: Molecular Mechanisms in Epigenetics. Blackwell Science).Turner B. Chromatin and gene regulation. Oxford, UK: Black- well ...
Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity The epigenetic regulation of chromatin structure and composition has often been studied molecularly in the context of specific DNA-dependent processes. How... Cavalli,G. - 《Development》 被引量: 145发表: 2006...
The overall aim of the Laboratory of Epigenetics and Gene Regulation based at the University of Cyprus is to understand how epigenetic mechanisms, such as those involving histone modifications, control the transcription of genes in thew context of health
1. With regard to plastic changes in DNA methylation and gene regulation induced by maternal environments (Fig. 2), associations between differential gene body methylation and differential gene expression or splicing were affected by interactions between differential methylation, chromatin accessibility, and...
GRN analysis requires an integration of multiple types of measurements including but not limited to gene expression, chromatin accessibility, transcription factor binding, methylation, and histone modification [7]. The challenge of GRN inference is that there exit hundreds of proteins and tens of thousa...
et al. (2010) The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression. Epigenetics 5, 758-766Stejskal S, Koutna I, Matula P et al: The role of chromatin condensa- tion during granulopoiesis in the regulation of gene cluster expression. Epigenetics...
In this review, we summarize and discuss the growing evidences connecting chromatin features and gene responsiveness. Keywords: epigenetics, gene responsiveness, histone modification, histone variant, memory, Arabidopsis, H2A.Z, H3K4me3 INTRODUCTION Gene expression patterns can change in response to ...
Chromatin modifications therefore participate in the dynamic regulation and specification of GnRH expression to differentiated hypothalamic neurons. 展开 关键词: Nuclear receptors Systems biology Bioinformatics Epigenetics Transcription DOI: 10.1210/me.2010-0403 被引量: 20 ...
The interplay between chromatin, transcription factors and genes generates complex regulatory circuits that can be represented as gene regulatory networks (GRNs). The study of GRNs is useful to understand how cellular identity is established, maintained and disrupted in disease. GRNs can be inferred...