Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of contr
found within the NuA4 acetyltransferase complex (Table1) and/or the Ino80 chromatin remodeling complex [97,98,100]. The NuA4 complex is a multi-subunit complex [107] involved in the acetylation of H2A.Z by its specific subunit Esa1 [107,108]. Esa1 and its mammalian homolog, Tip60, are...
et al. Ezh2–dCas9 and KRAB–dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin 12, 26 (2019). Article PubMed PubMed Central Google Scholar Stamatoyannopoulos, G. Control of globin gene expression during development and erythroid differentiation. ...
The interplay between chromatin, transcription factors and genes generates complex regulatory circuits that can be represented as gene regulatory networks (GRNs). The study of GRNs is useful to understand how cellular identity is established, maintained and disrupted in disease. GRNs can be inferred...
The overall aim of the Laboratory of Epigenetics and Gene Regulation based at the University of Cyprus is to understand how epigenetic mechanisms, such as those involving histone modifications, control the transcription of genes in thew context of health
Epigenes are defined as proteins that perform post-translational modification of histones or DNA, reading of post-translational modifications, form complexes with epigenetic factors or changing the general structure of chromatin. This specialized group o
Select Chapter 11 - Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA Book chapterAbstract only Chapter 11-Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA ...
BBA Gene Regulatory Mechanismsincludes reports that describe novel insights intomechanismsof transcriptional, post-transcriptional and translationalgene regulation. Special emphasis is placed on papers that identifyepigenetic mechanismsof gene regulation, including chromatin, modification, … ...
GRN analysis requires an integration of multiple types of measurements including but not limited to gene expression, chromatin accessibility, transcription factor binding, methylation, and histone modification [7]. The challenge of GRN inference is that there exit hundreds of proteins and tens of thousa...
Embryonic stem (ES) cells provide an important model system to study developmental regulation and hold significant potential for clinical therapeutics because of their unique capabilities to self re-new and differentiate into multiple lineages (reviewed in[1]). The chromatin of pluripotent ES cells hav...