PTCH1, a transporter-like tumor-suppressor protein, binds to Hh ligands, but SMO, a G-protein-coupled-receptor family oncoprotein, transmits the Hh signal across the membrane. Recent structural, biochemical and
Having demonstrated an interaction between GFs and cholesterol, we set out to test whether this interaction plays a role in mediating graphene’s cellular effects. We produced large films of planar graphene via chemical vapor deposition (CVD), which were solution transferred to bare glass coverslips...
Sub-cellular biochemistrySlotte, J. P. (1997). "Cholesterol-sphingomyelin interactions in cells--effects on lipid metabolism." Subcell Biochem 28: 277-93.J.P. Slotte, Cholesterol-sphingomyelin interactions in cells--effects on lipid metabolism, Sub-Cell. biochem. 28 (1997) 277 - 293....
One of the first reports on the role of membrane cholesterol in Alzheimer's was by Sparks et al. in 1994 [139]. Since then, many studies have tried to understand the role of cholesterol in Alzheimer's disease, but the results have been highly controversial. The activity of enzymes ...
2). However, each pathway produces distinct sterol intermediates which can have potent effects on cholesterol homeostasis and other cellular processes, independently of cholesterol. For example, 7DHC of the Kandutsch-Russell pathway is the precursor to vitamin D3, and desmosterol of the Bloch ...
While many studies have focused on derivation and molecular regulation of stem cells, relatively little is known about the composition of the stem cell membrane, the organization of which can critically affect cell responses to external stimuli. Cell membranes represent not only important cellular ...
Effects of sphingomyelin degradation on cholesterol mobilization and efflux to high-density lipoproteins in cultured fibroblasts The hydrolysis of sphingomyelin from cellular plasma membranes imposes many consequences on cellular cholesterol homeostasis by causing a rapid and dramati... JP Slotte,J Ten...
Cholesterol is an essential component of cellular membranes regulating the structural integrity and fluidity of biological bilayers and cellular processes such as signal transduction and membrane trafficking. However, tools to investigate the role and dy
As an essential structural component of eukaryotic cell membranes1,2, cholesterol is typically absent from bacterial cell membranes3. By leveraging on this difference, bacterial cells manage to evolve cholesterol-dependent cytolysins (CDCs), a family of bacterial protein toxins that form circular memb...
Several studies have shown that the bulk of cellular free cholesterol (FC) and sphingomyelin (SM) are localized in the plasma membrane (1, 2, 3). These two lipids interact strongly with each other in the membrane through hydrogen bonding and van der Waal's interactions (4, 5). It is...