PTCH1, a transporter-like tumor-suppressor protein, binds to Hh ligands, but SMO, a G-protein-coupled-receptor family oncoprotein, transmits the Hh signal across the membrane. Recent structural, biochemical and cell-biological studies have converged at the surprising model that a specific pool of...
Having demonstrated an interaction between GFs and cholesterol, we set out to test whether this interaction plays a role in mediating graphene’s cellular effects. We produced large films of planar graphene via chemical vapor deposition (CVD), which were solution transferred to bare glass coverslips...
These findings identify cholesterol as a mediator of graphene's cellular effects, providing insight into the biological impact of graphene. Understanding the biological role of graphene in eukaryotic cells is essential for future biomedicine applications. Here, the authors investigate the interaction of ...
The effects of cholesterol feeding on the membranes of liver cells and on the cholesterol metabolism in the rat 1. 1. Feeding of rats with a 2% cholesterol diet for 6 weeks increased the serum cholesterol concentration. The activity of lecithin cholesterol acyltransf... M Laitinen,J Marniemi,...
Fig. 6. Effects on aggregation of either γC-crystallin by αA-crystallin or human WS by αA-crystallin and UDCA or TUDCA: a Control γC-crystallin (0.0031 mM), γC-crystallin + αA-crystallin (0.02 mg/ml); γC-crystallin + αA-crystallin (0.04 mg/ml); or γC-crystallin...
It is vital in mediating the phase of lipid membranes as well as providing mechanical strength to cellular membranes, especially red blood cells [7]. As such, changes to the chemical structure of cholesterol can have significant consequences for the properties of cell membranes. It has been ...
The average effects on plasma cholesterol level for any given individual can be roughly predicted from the apoE genotype and can be considerable. Thus in the Nancy (France) series [70]the average cholesterol level for the ϵ2/ϵ2 homozygotes was 199 mg/dl and that for the ϵ4/ϵ4...
In conclusion, S100/calgranulin has no direct effect on cholesterol efflux in macrophages, but rather promotes the secretion of IL-22, which then directly reduces cholesterol efflux in macrophages by decreasing the expression of ABCG1. 展开 ...
While high protein diets have been shown to improve satiety and retention of lean body mass (LBM), this study was designed to determine effects of a protei... L Treyzon,S Chen,K Hong,... - 《Nutrition Journal》 被引量: 143发表: 2008年 Bioconjugated nanoparticles for DNA protection from...
As an essential structural component of eukaryotic cell membranes1,2, cholesterol is typically absent from bacterial cell membranes3. By leveraging on this difference, bacterial cells manage to evolve cholesterol-dependent cytolysins (CDCs), a family of bacterial protein toxins that form circular memb...