Single-cell RNA sequencing studies of differentiating systems have raised fundamental questions regarding the discrete versus continuous nature of both differentiation and cell fate. Here we present Palantir, an algorithm that models trajectories of differentiating cells by treating cell fate as a probabilis...
Cancer immunotherapies have shown sustained clinical responses in treating non-small-cell lung cancer1,2,3, but efficacy varies and depends in part on the amount and properties of tumor infiltrating lymphocytes4,5,6. To depict the baseline landscape of the composition, lineage and functional states...
Use of the FSP1 marker, therefore, should further facilitate both the in vivo studies of fibrogenesis and the mapping of cell fate among fibroblasts. 展开 关键词:Epithelium Cell Line 3T3 Cells Tumor Cells, Cultured Fibroblasts Epithelial Cells Animals Mice Calcium-Binding Proteins S100 Proteins ...
In summary, this study provides an interesting insight into mechanistic aspects of NuRD function in stem cell biology. The relevance of our work has broader implications because of the ubiquitous nature of the NuRD complex. The strategy described here can be more broadly applicable to investigate ...
- 《Journal of Biological Chemistry》 被引量: 666发表: 1997年 Notch and the Immune System Notch proteins are used repeatedly to direct developmental cell fate decisions in multiple organs. During hematopoiesis and immune development, Notch is cr... I Maillard,SH Adler,WS Pear - 《Immunity》 ...
YABBY proteins are widely distributed among different plant species and exhibit a higher degree of prevalence in angiosperms than in gymnosperms abaxial cell fate in the lateral organs of plants is mainly determined by the functions of YABBY genes. However, to date, no scientific study has been ...
The recent breakthrough of single-cell RNA sequencing (scRNA-seq) technique allows us to study the freshly isolated primary cells at single-cell resolution, and investigate the bona fide identity of human MSCs/SSCs in vivo.18On the other hand, based on the transcriptome of each cell, we coul...
The infrared spectrum of a mineral is a characteristic feature, which permits the identification of mineral species. The absorption bands arise from vibrations of the atoms or ions in the structure, and the frequencies of vibrations are dependent on the
Biology and transcriptomes of non-cancerous human mammary epithelial cells at risk for breast cancer development were explored following primary isolation utilizing conditional reprogramming cell technology from mastectomy tissue ipsilateral to invasive
Soybean is a promising biomass resource for generation of second-generation biofuels. Despite the utility of soybean cellulosic biomass and post-processing residues in biofuel generation, there is no comprehensive information available on cell wall loosening and degradation related gene families. In order...