Urban J, Technau GM (1997) Cell lineage and cell fate specification in the embryonic CNS of Drosophila. Cell Dev Biol 8:391-400. doi:10.1006/scdb.1997.0163Urban, J. and Technau, G. M. (1997). Cell Lineage and Cell Fate Specification in the Embryonic CNS of Drosophila. Semin. Cell ...
也就是同时测量cell fate and cell state。 同时,另外一种研究范式是phylogenetic lineage reconstruction methods或者叫retrospective lineage tracing, 他是从后往前去构建细胞的发育轨迹,基于phylogenetic reconstruction of endogenous genetic polymorphisms (that is, no experimental intervention). 从后往前mapped backward...
这个是斑马鱼领域的大牛,实验室在哈佛大学,他们主要的两个研究方向是:Vertebrate Development and Behavior:1.How do morphogens and gene regulatory networks determine cell fate, movement and differentiation? & 2.How do neuropeptides and neural circuits regulate sleep, wakefulness and other behaviors?他们组在...
Cell lineages are simple and invariant among individuals and have been described in detail. The clonal restriction of developmental fate takes place considerably early in development. I review here the temporal relationship between fate restriction, determination and initiation of lineage-specific gene ...
Furthermore, we reveal the transcription factor Zfp281 as a regulator of reprogramming outcome, biasing cells toward an off-target mesenchymal fate. Our results establish CellTag-multi as a lineage-tracing method compatible with multiple single-cell modalities and demonstrate its utility in revealing ...
We describe our studies of the cell fate pattern of these eight blastomeres, and find that the eight clones resulting from these cells set up distinct cell lineages that differ in terms of proliferation, migration and cell fate. Remarkably, the cell fate of each blastomere is restricted to a...
New approaches such as single-cell transcriptomics and the use of organoid models have led to the identification of the signals that guide fate specification of stem cell progeny into the six intestinal cell lineages. These cell types display context-dependent functionality and can adapt to different...
12月13日,Cell同期发表了两篇来自两个独立课题组的相似研究,一篇是来自中国科学院动物研究所周琪课题组与李伟课题组的合作研究论文Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos,另一个是来自英国剑桥Magdalena Zernicka-Goetz课题组的论文CARM1 and speckles Regulate Pre-implantation ...
Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions using expression similarity or RNA velocity to reconstruct state-change trajectories; however, trajectory inference does not incorporate valuable time point information or utilize additional modalities, whereas methods th...
Inductive signaling interactions between different cell types are a major mechanism for the further diversification of embryonic cell fates. Most blastomeres in the model chordate Ciona robusta become restricted to a single predominant fate between the 6