The molecular signature of megakaryocyte-erythroid progenitors reveals a role for the cell cycle in fate specification. Cell Rep. 25, 2083–2093 (2018). Article CAS PubMed PubMed Central Google Scholar Arinobu, Y. et al. Developmental checkpoints of the basophil/mast cell lineages in adult ...
Howard Chang, Ravindra Majeti and colleagues define the chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types and in acute myeloid leukemia cells. They identify potential regulators governing hematopoietic differenti
Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions using expression similarity or RNA velocity to reconstruct state-change trajectories; however, trajectory inference does not incorporate valuable time point information or utilize additional modalities, whereas methods th...
Inductive signaling interactions between different cell types are a major mechanism for the further diversification of embryonic cell fates. Most blastomeres in the model chordateCiona robustabecome restricted to a single predominant fate between the 64-cell and mid-gastrula stages. The deeply stereotyped...
STUDIES ON CELL FATE SPECIFICATION IN STRIATED MUSCLE LINEAGESJ, LiuA, Fire
2005). Cells of both AP and PP possess stem cell attributes, such as express pluripotent/mesenchymal stem cell markers, in vitro can be induced to differentiate into multiple cell lineages and self-renew (Li et al. 2009b; Wang et al. 2019). Therefore, antler generation and annual full ...
Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single
Integrative analysis of large-scale single-cell RNA sequencing (scRNA-seq) datasets can aggregate complementary biological information from different datasets. However, most existing methods fail to efficiently integrate multiple large-scale scRNA-seq da
The preimplantation period of embryogenesis encompasses the first cell-fate decisions of mammalian development and results in the derivation of three distinct cell lineages by the time of uterine implantation at the late blastocyst stage. Two of these lineages, the trophectoderm (TE) and primitive endo...
Important contributions to our current understanding of the developmental biology of schistosome intra-molluscan stages have been made using ‘bulk RNA-seq’20. In particular, two germinal cell lineages with distinct proliferation properties had previously been identified and functionally characterised by ‘...