Developmental biologists use fate mapping as a tool to trace cell lineages while an organism matures. This is done by labeling cells at an embryonic stage and then tracking them and their progeny throughout the organism’s development. Fate mapping is also used to study cell migration and differ...
High-resolution spatial transcriptomics and cell lineage analysis reveal spatiotemporal cell fate determination during craniofacial development Neural crest cells differentiate into distinct fates during craniofacial morphogenesis, though how these are acquired remains unclear. Here they show that mesenchymal pro...
STUDIES ON CELL FATE SPECIFICATION IN STRIATED MUSCLE LINEAGESJ, LiuA, Fire
The molecular signature of megakaryocyte-erythroid progenitors reveals a role for the cell cycle in fate specification. Cell Rep. 25, 2083–2093 (2018). Article CAS PubMed PubMed Central Google Scholar Arinobu, Y. et al. Developmental checkpoints of the basophil/mast cell lineages in adult ...
Inductive signaling interactions between different cell types are a major mechanism for the further diversification of embryonic cell fates. Most blastomeres in the model chordate Ciona robusta become restricted to a single predominant fate between the 6
Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions using expression similarity or RNA velocity to reconstruct state-change trajectories; however, trajectory inference does not incorporate valuable time point informat
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cells (MuSCs), pl
Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single
After this success, subsequent research revealed that cord blood cells exhibit remarkable differentiation capabilities, giving rise to erythroid, myeloid, and lymphoid cell lineages [37]. Fetal mesenchymal stem cells In the past, the prevailing belief was that the main source of MSCs was the bone ...
We took additional snapshots of single-cell transcriptomes during HSC-LC differentiation on post-induction days 3, 6, 9, and 12 (Figure 3A). Combined with the day 14 HSC-LC data (Figure S3A), we generated a compendium that revealed a cell fate continuum from HSCs to the diverse LC ...