In the present study, we examine previously postulated mechanisms underlying micro-deletions and micro-insertions such as slipped mispairing and strand switching, secondary loop excision and quasi-palindrome correction, Moebius loop resolution and excision in terms of local DNA sequence complexity. Indels...
A microarray-based technique to measure the relative amount of any DNA sequence. Paired-end mapping A technique whereby novel linkage relationships are detected by finding short sequences linked to other short sequences in DNA fragments of uniform size. Non-allelic homologous recombination Homologous ...
Log in Learn about institutional subscriptions Read our FAQs Contact customer support Data availability High-throughput sequencing data generated during the study (CHANGE-seq, GUIDE-seq, ATAC-seq, histone modification ChIP–seq) are available from the NCBI Sequence Read Archive and Gene Expression Omnib...
He also identified the DNA sequence needed to make the leptin “receptor”—the specialized proteins that stick out of brain cells involved in appetite regulation like microscopic antennae, sensing whenever leptin is present and kicking off a chemical cascade that promotes a sense of satiety. The...
DNA methylation of the vertebrate genome occurs predominantly at cytosine residues in cytosine-guanine dinucleotides (CpGs)1 (1). About 70% of CpGs are methylated, mainly in the repressive heterochromatin region and in repetitive sequences such as retrotransposable elements (2). Formation of the cel...
Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits. EMBO J. 16, 3066–3077 (1997). Article CAS PubMed PubMed Central Google Scholar Jones, P. M. & George, A...
In supervised learning, the goal of machine learning algorithms is to learn a function y from the set of features xn present in the training dataset. These features can represent any molecular signals, such as DNA sequence, expression of genes, proteins, metabolites or a set of pixels in ...
Out of the 47,065 contigs, 81.5% had positive BLASTx similarity hits with publicly available protein sequences. The E-value distribution of the top hits revealed that 98.7% of the mapped sequences showed significant homology (less than 1.0E-10,Supplementary Fig. S3A). ...
The first draft human mitochondrial DNA (mtDNA) sequence was published in 1981, paving the way for two decades of discovery linking mtDNA variation with hu... W Wei,PF Chinnery - 《Journal of Internal Medicine》 被引量: 0发表: 2020年 Implications of Allee effects for fisheries management in...
More specifically, the present invention relates to a method for enzymatically inactivating a target DNA, to a method for detecting conformational change in a nucleic acid and to hybrid molecules comprised of a sequence-specific nucleic acid binding domain joined to a detection domain. 2. Description...