Ono T, Okada S, Kawakami T, Honjo T, Getz MJ (1985) Absence of gross change in primary DNA sequence during aging process of mice. Mech Ageing Dev 32(2-3):227-234Ono T, Okada S, Kawakami T, Honjo T, Getz MJ. 1985. Absence of gross change in primary DNA sequence during aging ...
Significant decreases in total and integrated HIV-1 DNA were observed during the first 15 months of suppressive therapy before the concentrations became stable. Clonal analysis of HIV-1 pol demonstrated that the proportions of resistance mutations in DNA sequences after 2 years were lower than those...
functional hermaphroditism is a unique strategy2that has been adopted by at least 27 families across seven orders of teleosts, mainly in the coral reef environment3. Insimultaneous
The methylation of intracisternal A-type particle () sequences is maintained during . Methylation suppresses expression and the potential for by retrotrans... F Gaudet,WM Rideout,A Meissner,... - 《Molecular & Cellular Biology》 被引量: 296发表: 2004年 Stage-specific alterations of DNA methylt...
A microarray-based technique to measure the relative amount of any DNA sequence. Paired-end mapping A technique whereby novel linkage relationships are detected by finding short sequences linked to other short sequences in DNA fragments of uniform size. Non-allelic homologous recombination Homologous ...
Sequence-specific DNA-binding proteins play a key role in many fundamental biological processes, such as transcription, DNA replication and recombination. Very often, these DNA-binding proteins introduce structural changes to the target DNA-binding sites including DNA bending, twisting or untwisting and...
The magnitude of this contribution depends on the exact DNA sequence. A detailed analysis revealed that the largest flexibility changes occurred in the sugar-phosphate backbone, resulting in an entropy gain in the most cases. The nucleobases were not involved in the changes of flexibility and ...
DNA sequence-dependent conformational changes induced by the minor groove binder, distamycin, have been evaluated by polyacrylamide gel electrophoresis. The distamycin binding affinity, cooperativity, and stoichiometry with three target DNA sequences that have different sizes of alternating AT sites, ATAT,...
Ectopic recombination between locally repeated DNA sequences is of fundamental importance in the evolution of gene families, generating copy-number variation in human DNA and often leading to pathological rearrangements. Despite its importance, little is known about the dynamics and processes of these un...
We conclude that a gene's position in the chromosome, rather than its sequence, determines the time of replication. We suggest that the differences in association with gene rearrangement result from changes in the proximity of the affected gene to sites that control the temporal order of ...