The engine underlying TrendSegment is a new Tail-Greedy Unbalanced Wavelet (TGUW) transform: a conditionally orthonormal, bottom-up transformation for univariate data sequences through an adaptively constructed
structurally similar to ESR1 and ESR212but whose ligands are unknown. ESRRA also has DNA sequence homology to the estrogen receptor and can be activated by phytoestrogens (i.e. genistein)13. These receptors play pivotal roles in metabolism, insulin resistance, NAFLD, and mitochondrial function12. ...
Comparing between any two cell types, environmental conditions or species, there are typically thousands of molecular differences such as changes in gene expression, making this a difficult question to answer. We reasoned that one way to address this question would be to ask it in a minimal syste...
However, the sequence and location of TDMRs in the genome were largely unknown. The advent of the mouse and human genome project and virtual RLGS [4], [5], [6] has made it possible to more rapidly identify the DNA sequence of RLGS fragments and the locations of TDMRs [7], [8], ...
In other trinucleotide repeat disorders, such as DM1, FA and FRAXA, an increase in DNA methylation upstream of the repeat expansion tracts was suggested as a pathogenic mechanism. These diseases are characterized by large expansions (> 100 repeats) in non-coding sequences, and their ...
Transcription factors (TFs) interpret the genome directly, and are responsible for decoding DNA sequences [1]. It is reported that transcriptional factors are key components of cells that control gene expression, determining how the cells function [2]. Transcription factors acting as conductor orchest...
The binding partners of DPO4 in the crystal structures (DNA or PCNA12) are not shown in (C)–(E). DPO4 sequence (y axis) is colored for different domains in (F), with the same color in (C)–(E). The native contacts are determined with Shadow Algorithm Noel et al., 2012, Noel...
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into totipotent-like 2-cell-like cell
Maternal nutrition during pregnancy can induce epigenetic alterations in the fetal genome, such as changes in DNA methylation. It remains unclear whether these epigenetic alterations due to changes in maternal nutrition are transitory or persist over time. Here, we hypothesized that maternal methionine ...
BMC Ecol Evo (2021) 21:39 Page 2 of 16 is of great interest in understanding the long-term behav- iour of coding sequences [7]. For protein-coding DNA, the effects of selection are most frequently studied through characterising the rate of non-synonymous substitutions (dN) in comparison ...