ChangepointsDNA sequence analysisKolmogorov–Smirnov statisticsNon-coding deoxyribonucleic acid (DNA) can typically be modelled by a sequence of Bernoulli random variables by coding one base, e.g. T, as 1 and other bases as 0. If a segment of a sequence is functionally important, the ...
DNA SEQUENCE FOR EXPRESSION IN AN E. COLI HOST OF A POLYPEPTIDE WITH THE PROPERTIES OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AND ITS USE IN THE PRODUCTION O... AR Banks,GM Fox 被引量: 0发表: 1991年 Prominent expression of acidic fibroblast growth factor in motor and sensory neurons Several...
We conclude that a gene's position in the chromosome, rather than its sequence, determines the time of replication. We suggest that the differences in association with gene rearrangement result from changes in the proximity of the affected gene to sites that control the temporal order of ...
As expected, the average constraint for protein-coding sequences is stronger than that for non-coding regions. Within the non-coding genome, constrained regions are enriched for known regulatory elements and variants that are implicated in complex human diseases and traits, facilitating the ...
Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we still lack a systematic mapping from any sequence or variant to regulatory activities. We address this challenge with Sei, a framework for integrating human geneti
eichingeri IRGC acc105163, and detected it in 25 introgression lines. This repetitive DNA sequence showed high specificity to the rice CC genome, but was absent from all the four tetraploid species with BBCC or CCDD genomes. The monomer in this repetitive DNA sequence is 325–366-bp long, ...
or homology directed repair where a homologous piece of DNA is used as a repair template. It is the latter which allows precise genome editing: the homologous section of DNA with the required sequence change may be delivered with the Cas9 nuclease and sgRNA, theoretically allowing changes as pre...
A polymorphism in the repetitive (TGGA)n sequence 5' to the human myelin basic protein gene in Italian multiple sclerosis patients. Guerini FR, Losciale L, Mediati M, et al. A polymorphism in the repetitive (TGGA)n sequence 5’ to the human myelin basic protein gene in Italian multiple ...
Supplementary Tables 1 (PCR primer sequences) and 2 (list of siRNAs). Supplementary Video 1 CLEM of structures containing extra-mitochondrial mtDNA in a U2OS cell expressing UL12.5. TFAM–GFP was imaged as a marker for extra-mtDNA in a fixed, UL12.5-expressing cell. The same cell was image...
aDNA序列分析的另外一钟方法是发展高速平行操作工艺。例如,Sydney Brenner首创了一种方法,他们能够同时测定一百万条基因的序列。 The DNA sequence analysis other clock method is the development high speed parallel operation craft.For example, Sydney Brenner originated one method, they can simultaneously determin...