DNA Sequence Changes in the Gene encoding the GM-CSF / IL-3 / IL-5 Receptor Common |[beta]| Chain in Infants with Pulmonary Alveolar ProteinosisPediatric Research publishes original papers, invited reviews, and
The engine underlying TrendSegment is a new Tail-Greedy Unbalanced Wavelet (TGUW) transform: a conditionally orthonormal, bottom-up transformation for univariate data sequences through an adaptively constructed unbalanced wavelet basis, which results in a sparse representation of the data. In this ...
Here, we report high-quality sequences of both Ath Ler and Aar genomes in resynthesized allotetraploids and two subgenomes of naturalA. suecica. Using these sequences, we studied genomic variation, DNA methylation and gene expression changes between the progenitors and their related subgenomes in ...
DNA methylation is a conserved epigenetic mechanism with a well-known role in cell fate specification [5, 6]. In mice, this function appears to be essential for organismal development, as genetic deficiencies for DNA methyltransferases cause severe developmental phenotypes and embryonic lethality [7,...
Scientists measured this by studying the ends of children’s chromosomes(染色体), called telomeres, says Idan Shalev, lead author of a study published in Molecular Psychiatry. Telomeres are special DNA sequences which prevent the DNA in chromosomes from separating. They get shorter each time a cel...
TCF4 is a member of the class I basic-helix-loop-helix (bHLH) family of transcription factors, that bind to the DNA motif called E-box ('CANNTG') and modulate transcrip- tion. These E-box regulatory sites found in promoters and enhancer elements of numerous genes regulate tissue-spe- ...
mutation site and the latest sequence text manually, we found several differences between relative and absolute positions of sequence first residue in proteins and corrected them to make the attached sequence information consistent with the training dataset; the final integrated dataset was called M3131...
We take these results to indicate that cells of the rat host cannot support VZV DNA replication and virus amplification. This is consistent with the minimal expression from VZV late genes in the dual fluorescence VZV infection studies. Taken together, these results establish that VZV productive ...
Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+T cell regulatory elements1,2,3. Understanding how genetic variation affects gene expression in different T cell physiological states is essential for deciphering genetic mechanisms of autoimmunity4,5. ...
In neurons affected by Alzheimer’s disease, additional DNA alterations are driven by distinct processes (signature C) that highlight C>A and other specific nucleotide changes. These changes potentially implicate nucleotide oxidation4,11, which we show is increased in Alzheimer’s-disease-affected ...