cGMP-PKG signaling pathway Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms ...
Sildenafil (Sil) increases cGMP and inhibits RhoA, and this intracellular pathway has pronounced effects on NHE3 activity. The aim of this work was to determine the effects of Sildenafil on NHE3 and to study the intracellular signaling pathway involved. The studies were performed by the ...
cGMP/PKG Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of CNG Channel-Deficient Mice: H. Ma, et al.; J. Biol. Chem. (2015), Application(s):ELISA using mouse retinal lysate,Abstract;Full Text Heterozygous NPR2...
& Oka, K. NO/cGMP/PKG signaling pathway induces magnesium release mediatedRyu Yamanaka,Yutaka Shindo,Kohji Hotta,Koji Suzuki,Kotaro Oka.NO/cGMP/PKG signaling pathway induces magnesium release mediated by mitoK ATP channel opening in rat hippocampal neurons[J]. FEBS Letters .2013...
We conclude that changes in gene expression may influence the Ca2+ mobilization pathway in ChD, and AS impacts the genes involved in cGMP/PKG/Ca2+ signaling pathway in ChD and diabetes. Our findings suggest that ChD patients with diabetes may be at increased risk of cardiomyopathy and heart ...
Essential roles of the nitric oxide (no)/ cGMP/protein kinase G type-Iα (PKG-Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG-Iα autocrine loop in promoting proliferation and cell survival of OP9 bone marrow stromal cells. J Cell Biochem 2011; 112: 829-839 [...
fibroblast activation through suppressing autophagy by inhibiting the ERK signaling pathway.#Our findings suggest that autophagy plays a pivotal role in promoting BPH progression through fibroblast activation, while PDE5Is effectively suppress autophagy and fibroblast activation via the ERK signaling pathway....
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling PathwayXin DengQianfeng WuDong LiYouping Liu
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling PathwayXin DengQianfeng WuDong LiYouping Liu
Conclusion LFG exhibited the lipid-lowering effect, which might be attributed to downregulating ADRB2 and NOS3, and upregulating LDLR through the cGMP-PKG signaling pathway in hyperlipidemia rat. Ferulic acid and p-hydroxybenzoic acid might be the underlying active ingredients which affect the ...