Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which extraskeletal (heterotopic) bone forms within tissues such as skeletal muscles, often in response to injury. Mutations in the BMP type I receptor ACVR1/ALK2 cause FOP by increasing BMP pathway signaling. In contrast ...
Transcriptional reprogramming of skeletal muscle stem cells by the niche environment Felicia Lazure, Rick Farouni, Korin Sahinyan, Darren M. Blackburn, Aldo Hernández-Corchado, Gabrielle Perron, Tianyuan Lu, Adrien Osakwe, Jiannis Ragoussis, Colin Crist, Theodore J. Perkins, Arezu...
One of the most obvious results of exercise is to get function and health state of skeletal muscles improved [55]. The process of myogenic differentiation of stem cells can be divided into two stages. The first stage is cell division, and the second stage is cell differentiation characterized ...
Regeneration of skeletal muscle. Time course of changes in cellular composition during skeletal muscle regeneration following cardiotoxin (CTX) injury. Satellite cells (in green) are quiescent in resting skeletal muscle. Five days after CTX injury, regenerating muscles are reduced to mostly mono-nuclear...
Usually, each cell has exactly one nucleus. But the cells of our skeletal muscles are different: These long, fibrous cells have a comparatively large cytoplasm that contains hundreds of nuclei. But up to now, we have known very little about the extent to which the nuclei of a single muscle...
The above statement has fully manifested the essential role of macrophages in the inflammation of damaged skeletal muscles, the phenotypic switch of which is necessary to complete the whole repair process, with Treg cells exactly serving as the key to the control over that. In a mouse skeletal ...
Skeletal muscle (found in muscles attached to the skeleton) is one of the three types of muscle present in the body, in addition to the cardiac muscle (found in the heart) and smooth muscle (found in hollow organs throughout the body. Unlike smooth muscle, which is controlled involuntarily...
Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as precursors for muscle growth and repair. Although t... M Cerletti,S Jurga,CA Witczak,... - 《Ce...
The three types of muscle tissue in the body include cardiac, smooth and skeletal. The heart is the only location of the cardiac muscle tissue and these are involuntary muscles allowing the heart to beat continuously. The smooth muscle tissue lines the hollow organs (except th...
Additionally, the absolute numbers of satellite cells increases in the soleus but not the EDL between 1 and 12 months of age, although the proportion of satellite cells decreases in both muscle types with increasing age [20]. In humans, the proportion of satellite cells in skeletal muscles ...