Development is the story of how stem cells multiply and specialise to differentiate into specific cell types which will make the tissues, organs and systems of the adult organism. In this chapter, this concept is illustrated by the example of the development of one tissue, namely skeletal muscle...
abe confident 正在翻译,请等待...[translate] a其中骨骼肌的肌细胞的形状细长,呈纤维状,故肌细胞通常称为肌纤维。 Skeletal muscle muscle cell shape is tall and slender, assumes fibrously, therefore the muscle cell usually is called the muscle fiber.[translate]...
Stem cells have become a hot research topic in the field of regenerative medicine due to their self-renewal and differentiation capabilities. Skeletal muscle tissue is one of the most important tissues in the human body, and it is difficult to recover when severely damaged. However, conventional ...
the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling pathways as well as by interactions with the stem cell niche. Here, we discuss the properties of ...
Conditions involving muscle wasting, such as muscular dystrophies, cachexia, and sarcopenia, would benefit from approaches that promote skeletal muscle regeneration. Stem cells are particularly attractive because they are able to differentiate into specialized cell types while retaining the ability to self...
2). To selectively increase the number of MuSCs, FAPs and macrophages for clustering and downstream analysis, we used FACS to enrich for the three cell types mentioned as an alternative to sequencing whole muscle cell suspension (Fig. 1b, Supplementary Fig. 1). In addition to an overall ...
Satellite cells assure postnatal skeletal muscle growth and repair. Despite extensive studies, their stem cell character remains largely undefined. Using p... V Shinin,B Gayraud-Morel,D Gomès,... - 《Nature Cell Biology》 被引量: 871发表: 2006年 Regulation and Function of Skeletal Muscle Stem...
Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation. Exp Hematol 2002; 30:1339-1345. 5 Asakura A. Stem cells in adult skeletal muscle. Trends Cardiovasc Med 2003; 13:123-128. 6 Gussoni E, Soneoka Y, Strickland CD, et al. Dystrophin expres...
It is well-known that satellite cells are important to postnatal skeletal muscle growth [1] and skeletal muscle regeneration in adult skeletal muscle [2, 3]. Almost fifty years of research with isolated satellite cells has focused on the activation and inhibition of their proliferation [4], ...
Specific, high-affinity binding of FGF2 was evaluated in cultured skeletal muscle satellite cells from young (3- to 4-week-old) and adult (9- to 12-month-old) rats prior to the first division in culture. Specific binding of FGF2 was detected on satellite cells from young rats at 18 h...