All muscle stem cells (except the ones forming the muscles of the head) arise from specific transient mesodermal structures of early embryos called dermomyotomes. Along embryonic, then foetal and post-natal development, these cells are specified by a combination of different signals. They respond ...
Muscles are linked to bones by tendons or tendon-like structures through which the forces and movements developed by muscle contractions are transmitted to the skeleton. Contractions of skeletal muscles provide the stability and power for all body movements. Thus, any impairment in skeletal muscle ...
Explain the process of contraction in a skeletal muscle, starting with how the signal enters a muscle cell at the neuromuscular junction. Include all relevant ions, structures, and processes in the explanation. How would you explain the skeletal muscle cell contraction wer...
The satellite cell and stromal cell niche. Satellite cells states are regulated through their interactions with their microenvironment. While direct interactions (M-cadherin, Notch pathway)38,46and communication (FGF2-FGFR1 pathway)48between muscle fibres and satellite cells have been identified, muscle ...
at Dortmund.In the last couple years, we switched part of our work from single particle cryo-EM tocryo-electron tomography(cryo-ET). The reason is that we got more interested in how the protein structures we solved are interacting with other proteins inside the cell in the natural ...
Skeletal muscle size and function are tightly regulated by the balance between the processes controlling muscle protein synthesis (MPS) and degradation. When adult skeletal muscle grows, it does so by increasing the size of each cell much more than the number of cells [5]. This growth is ...
(non-myogenic cells and molecular structures) in the regulation of skeletal muscle regeneration. Myogenic cell environment includes inflammatory cells and particularly macrophages, vessel cells (endothelial and peri-endothelial cells) and interstitial cells. We aim at understanding the interactions between ...
cell attachment and proliferation with evidence of tube-like structures (Fig.4A). Separately, a coculture of motor neurons and endothelial cells were generated by initially plating motor neurons on PDL/laminin-coated multiwell plates for 7 days followed by addition of endothelial cells and ...
and photolithography are commonly used to create microfibrous structures and 2D grooved surfaces. On the other hand, most approaches are confined to the creation of 2D microstructures wherein the seeded cells cannot produce the actual structure and function of 3D muscle tissues. However, creating 3D...
and a regulatory network centered on Treg cells is summarized. The present study summarizes the cell-mediated interactions in skeletal muscle repair over the past decade, and elucidates the central role of regulatory T cells in this process, so that other researchers can more quickly and comprehensi...