For the thymic development of iNKT cells, homotypic interactions between immature thymocytes with SLAM-SAP signaling are critical46. For their effector differentiation into NKT1, NKT2, and NKT17 cells, various combination of cytokine and transcription factors are also required. These features are also...
While MuSC clusters 1 and 2 are very similar in their gene expression profiles, there are certain genes and pathways that differentiate the two (Fig. 2c, e, f). MuSC Cluster 1 is also reduced in aging, albeit to a lesser extent than Cluster 3 (Fig. 1e). MuSC Cluster 1 is character...
EMT signalling pathways (EPITHELIAL MESENCHYMAL TRANSITION), myogenesis and other muscle-related signalling (Fig.S5A). Moreover, the gene ontology (GO) demonstrated that the DEGs were mainly enriched in cell motility and even in myofibrils, extracellular matrix organization, and extracellular structure ...
Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, Volume 36, Issue 12, 2021, Article 109726 Jianping Hu,…, Hong Li View PDF Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level bra...
These findings implicate IL12-GEMy cell therapy in reducing a multitude of diverse signaling pathways within the pre-metastatic niche that can contribute to the core immune suppression program. To further elucidate the contribution of specific cell types to the IL12-GEMy response, we examined the ...
The three key things from the in silico simulation and experimental results are: 1) palmitate induces different signaling pathways (PKR (double-stranded RNA-activated protein kinase), PERK (PKR-like ER kinase), PKA (cyclic AMP (cAMP)-dependent protein kinase A) in a time dependent-manner, 2...
We also investigated the interaction between ESCs and other cells types to identify potential signaling pathways that regulate endometrial receptivity and embryo implantation. 2. Results 2.1. Single-Cell RNA-Sequencing of thePregnant Mouse Uterus To understand the transcriptional changes in different cell...
To compute the amount of information needed to describe/build the target SC the total number of possible combinations is needed. In this case N = 2 · 32 = 18 and the amount of information (log2 18) is 4.17 bits (5 bits). Organization. Following a similar operational approach, the ...
EFEMP1 is particularly interesting from a therapeutic perspective because it is connected to several potentially druggable pathways, including complement activation, the EGF receptor, and BMP7 and TGFβ2 signaling [110, 123,124,125]. In addition, EFEMP1, as a protein secreted into the ...
We used this information to compute the observed-to-expected ratio (obs/exp) for double-positive events, namely the ratio of observed TLR7+ TLR8+ cell counts to the expected number of cells in this stratum assuming transcriptional independence between TLR7 and TLR8. Non-independence would be ...