Cardiac Cell-ECM Interactions: A Possible Site for Mechanical SignalingThe cardiac interstitium is a diverse system of extracellular matrix (EMC) components organized into a stress-tolerant three-dimensional network that interconnects the cellular components of the heart. At the molecular level, the ECM...
The Dynamics of Cell-ECM Interactions, with Implications for Tissue Engineering Authors: M. Petreaca, M Martins-Green See all similar Cited by1 The role and regulation of integrins in cell migration and invasion Authors: Megan R. Chastney, Jasmin Kaivola, Veli-Matti Leppänen … See all...
We used a novel 3D culture concept to assess cell–matrix interactions implicated in carcinogenesis: a synthetic hydrogel matrix equipped with key biomimetic features, namely incorporated cell integrin-binding motifs (e.g. RGD peptides) and the ability of being degraded by cell-secreted proteases (...
Interactions of cells with extracellular matrix molecules play a crucial role in development. There is continuous crosstalk between cells and molecules of the extracellular matrix which leads to development of patterns, morphogenesis, differentiation and maintenance of the differentiated phenotype. Many specif...
Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer - ScienceDirect Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer - ScienceDirectSpheroid... Yu Bin Lee a b,Eun Mi Kim a b,...
B Quantitative visualization of representative simulated cell-ECM interactions (left) and cell-ECM-cell communication (right) at the onset (“begin”) and after (“end”) 50% cell contraction. Color code encodes the ECM density in z-score, the number of standard deviations above background ...
Higher invasive potential of cells upon EMT may also be attributed to greater cell–ECM interactions leading to greater ECM degradation84,85. Together, these results highlight the sensitivity of single cell invasion to MMP secretion rate. In vivo, the collagen-rich interstitial matrix is known to...
Here, we show that front-rear cell polarization based on the relative positions of nucleus and microtubule organizing center is precisely controlled by mechanical interactions including cellular adhesion to extracellular matrix and nucleus-cytoskeletal connections. By modulating the size and distribution of ...
We used a novel 3D culture concept to assess cell–matrix interactions implicated in carcinogenesis: a synthetic hydrogel matrix equipped with key biomimetic features, namely incorporated cell integrin-binding motifs (e.g. RGD peptides) and the ability of being degraded by cell-secreted proteases (...
Cells express various cell adhesion molecules (CAM) that mediate cell–cell or cell-ECM contacts (Fig.3) [23]. The cell-ECM linkage is a focal adhesion, which relies on integral protein-actin interactions [24]. The adhesion belt is responsible for cell–cell contacts, with the main proteins...