The extracellular matrix (ECM) consists of a plex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transme...
or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between ...
Meanwhile, the protein-protein interaction (PPI) network was constructed to predict the interactions of the DEGs using STRING (Search Tool for the Retrieval of Interacting Genes) database. Function enrichment analysis was then performed with GSEA (Gene Set Enrichment Analysis) method to reveal the ...
18 Int J Clin Exp Med 2016;9(1):9-20 Potential signaling pathway analysis of primary osteoporosis Another two pathways, focal adhesion and ECM-receptor interactions were significantly up-regulated in the enrichment analysis. The genes related to focal adhesion and ECM- receptor pathway were ...
(PPI)networkwasconstructedtopredicttheinteractionsoftheDEGsusingSTRING(SearchToolfortheRetrievalofInteractingGenes)database.FunctionenrichmentanalysiswasthenperformedwithGSEA(GeneSetEnrichmentAnalysis)methodtorevealthebiologicalprocess,signalingpathwayandtran-scriptionfactorsinvolvedinprimaryosteoporosis.Atotalof406DEGswere...
Different laminins were up-regulated in the different depots. This comparative transcriptome analysis of three adipose tissues suggested that the interactions between ECM components and transmembrane receptors of fat cells depend on the depot specific adipogenesis. 展开 ...
The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated prot... MD Rosso,G Fibbi,M Pucci,... - 《Clinical & Experimental Metastasis》 被引量: 220发表: 2002年 Epithelial-to-mesenchymal transition and ova...
关键词: protein–protein interactions genetic variants atrial fibrillation atrial fibrillation recurrence atrial fibrillation progression calcium signaling ECM–receptor interaction DOI: 10.3389/fgene.2018.00162 年份: 2018 收藏 引用 批量引用 报错 分享
The interactions between the ECM and the glioblastoma microenvironment are important in this progression [74]. During tumor metastasis, tumor cells pass through the ECM, and the tumor suppressor nischarin may prevent cancer cell migration by interacting with many proteins [75]. Some studies have ...
Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specic Adipogenesis in Cattle.doc 2017-05-06上传 Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specic Adipogenesis in ...