1、CCIs relay signals between cells and trigger downstream signaling events that culminate in altered gene expression.(基础认知)。 2、通过这些和其他功能相互作用,CCI 形成相互作用的空间模式并调节集体细胞行为。 3、(划一下重点)CCIs often take the form of secreted or surface proteins produced by a se...
14. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A: Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.Cell2013, 153(2):376-388. 15. Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty...
24. Shao L-W, Niu R, Liu Y. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 2016;26(11):1182-96. doi:10.1038/cr.2016.118. 25. Zhang Q, Wu X, Chen P, Liu L, Xin N, Tian Y et al. T...
The network of biomolecules that serve to transmit signals and induce cellular responses. Post-translational modification of proteins is the most common way signals are propagated. Fuzzy logic Extension of standard Boolean logic to define truth values of variables, encompassing real values between 0 and...
Glucagon is hormone that signals via a dedicated g-protein coupled receptor, but downstream signaling is poorly understood. Here, Wu et al. uncover liver glucagon signaling using phosphoproteomics and define a role for the vesicle trafficking protein SEC22B in distinct metabolic actions. ...
细胞类型组成与原型遗传性损伤相关,包括FLT3-ITD与大量祖细胞样细胞相关。原始AML细胞表现出转录程序失调,with co-expression of stemness and myeloid priming genes and had prognostic significance。 介绍 1、AML是一种恶性肿瘤(其特征在于髓系谱系的未成熟细胞的积累),5年内复发率达到75%,对于AML的复发与遗传性...
S2B). Importantly, we verified that these gRNA assignments were consistent with gRNA transcripts recovered in the gene expression library, confirming that the PCR enrichment process does not introduce spurious signals (Additional file 1: Fig. S2C). As cells were transduced at low MOI, we ...
Juxtacrinesignalstargetadjacent(touching)cells.Thesesignalsaretransmittedalongcellmembranesviaproteinorlipidcomponentsintegraltothemembraneandarecapableofaffectingeithertheemittingcellorcellsimmediatelyadjacent.SignalingReceptor •Acelltargetedbyaparticularchemicalsignalhasareceptorproteinthatrecognizesthesignalmolecule.•The...
6.XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells XIST直接调控初始人类多能干细胞的X连锁和常染色体基因 摘要:X chromosome inactivation(XCI)serves as a paradigm for RNA-mediated regulation of ge...
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene 34, 3095–3106 (2015). Article CAS PubMed Google Scholar Aylon, Y. et al. The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. Genes Dev. 30, 786–...