1、CCIs relay signals between cells and trigger downstream signaling events that culminate in altered gene expression.(基础认知)。 2、通过这些和其他功能相互作用,CCI 形成相互作用的空间模式并调节集体细胞行为。 3、(划一下重点)CCIs often take the form of secreted or surface proteins produced by a se...
Here the authors show that the patterning signals WNT, BMP, and FGF control chromosome segregation fidelity during early lineage specification and neurogenesis, which could provide a rationale for the spatio-temporal distribution of genomic mosaicism during human development. Anchel de Jaime-Soguero , ...
AML cells,HSC/Prog signature genes and GMP signature genes were frequently co-expressed in the same malignant cells, markedly contrasting with their exclusivity in normal hematopoiesis.We found that patients with higherHSC/Prog-like signals, whose tumors presumably contain more primitive LSCs, had sign...
24. Shao L-W, Niu R, Liu Y. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 2016;26(11):1182-96. doi:10.1038/cr.2016.118. 25. Zhang Q, Wu X, Chen P, Liu L, Xin N, Tian Y et al. T...
The network of biomolecules that serve to transmit signals and induce cellular responses. Post-translational modification of proteins is the most common way signals are propagated. Fuzzy logic Extension of standard Boolean logic to define truth values of variables, encompassing real values between 0 and...
S2B). Importantly, we verified that these gRNA assignments were consistent with gRNA transcripts recovered in the gene expression library, confirming that the PCR enrichment process does not introduce spurious signals (Additional file 1: Fig. S2C). As cells were transduced at low MOI, we ...
The bifurcation of cAMP signals in neurons and other cell types where it can bind to and activate both PKA and Epac, shows the origins of a signaling network where a single signal (cAMP) can be routed to two differentprotein kinases(PKA and MAP-kinase 1, 2). These protein kinases have ...
andeffectthetargetcellitselfviareceptors.Sometimesautocrinecellscantargetcellsclosebyiftheyarethesametypeofcellastheemittingcell.Anexampleofthisareimmunecells.Juxtacrinesignalstargetadjacent(touching)cells.Thesesignalsaretransmittedalongcellmembranesviaproteinorlipidcomponentsintegraltothemembraneandarecapableofaffectingeither...
Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework Controlled exchange of protein and nucleic acid signals from and between synthetic minimal cells The trade-off between individual metabolic specialization and versatility determines the metaboli...
6.XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells XIST直接调控初始人类多能干细胞的X连锁和常染色体基因 摘要:X chromosome inactivation(XCI)serves as a paradigm for RNA-mediated regulation of ge...