细胞信号通路(Cell Signaling).ppt,* * * * * * * * * * For example, after the?epidermal growth factor (EGF)?receptor binds with its ligand EGF, two receptors dimerize and then undergo?phosphorylation?of the tyrosine?residues in the enzyme portion of each r
? This process goes wrong in cancer, and cells keep on dividing. Organised tissue Disorganise d tumour 13 The three stages of cell signaling Signal reception: receptors Signal transduction: from outside to inside Cellular response: gene expression 14 in cell channel-linked membrane (integral G-...
细胞信号转导Cell signaling-graduate 2016.ppt,Protein-Protein Interaction Basis of cell signaling dynamic, specificity, amplification, …… Mediated by protein modification mostly Protein post-translation modification > 200 kinds Phosphorylation, Ubiquiti
细胞信号通路(Cell Signaling)CellSignaling •Cellsignallingispartofacomplexsystemofcommunicationthatgovernsbasiccellularactivitiesandcoordinatescellactions.•Theabilityofcellstoperceiveandcorrectlyrespondtotheirmicroenvironmentisthebasisofdevelopment,tissuerepair,andimmunityaswellasnormaltissuehomeostasis.•Errorsincellular...
细胞信号通路(Cell Signaling)CellSignaling •Cellsignallingispartofacomplexsystemofcommunicationthatgovernsbasiccellularactivitiesandcoordinatescellactions.•Theabilityofcellstoperceiveandcorrectlyrespondtotheirmicroenvironmentisthebasisofdevelopment,tissuerepair,andimmunityaswellasnormaltissuehomeostasis.•Errorsincellular...
Describe the structure of G-protein and its activation ? ? ? ?Signaling through Enzyme-Linked Cell-Surface Receptors ?Enzyme-linked receptor: Major type of cell-surface receptor in which the cytoplasmic domain either has enzymatic activity itself or is associated with an intracellular enzyme. In ...
Cellmustrespondappropriatelytoexternalstimulitosurvive.Cellsrespondtostimuliviacellsignaling A.Theformsofcellcommunication---Differenttypesofchemicalsignalscanbereceivedbycells 1.分泌化学信号(内分泌、旁分泌、自分泌和化学突触);2.接触依赖性通讯;3.通过细胞连接的通讯 接触依赖性通讯旁分泌 自分泌 如胚胎发育中 Fi...
Cells can interact with each other and with their environment ? This interaction turns specific signaling paths ON or OFF ? These pathways become important for mediating proliferation, differentiation and apoptosis All three above are crucial to development Extracellular Signals for Differentiation ...
Function as signaling sites Glycocalyx: carbohydrate-rich molecules external to the plasma membrane Membranes are constantly changing Membranes are constantly forming, transforming from one type to another, fusing with one another, and breaking down ...
Chapter6:CellSignaling(第八章) Chapter7:CytoskeletonSystem(第九章) Chapter8:NucleusandChromosomes(第十章) Chapter9:Ribosome(第十一章) Chapter10:Cellproliferationanditsregulation(第十二章) Chapter11:Cellapoptosisandcellularaging(第十三章) Chapter12:Celldifferentiationandgeneexpression(第十四章) ...