Thus, although the three Met oncogenes examined are similar in their dependency on a number of specific tyrosines for activity, the signaling strategy employed by Tpr-Met can be differentiated from that of the other two. 展开 关键词: Met oncogene signaling ...
Several laboratories have measured lateral diffusion of single particles on the cell surface, and these measurements may reveal an otherwise inaccessible level of submicroscopic organization of cell membranes. Pitfalls in the interpretat... J M.,Saxton - 《Biophysical Journal》 被引量: 821发表: 1993...
We further demonstrate that the formation of this MPZL1-PTPN11-GRB2 complex is triggered by cell attachment to fibronectin. Thus, our data support the importance of this new signalling complex in the control of cell adhesion of HER2+ breast cancer cells, a key feature of the metastatic process...
MAPK signaling pathwaycell deathPhenethyl isothiocyanate (PEITC) is an isothiocyanate that largely exists in cruciferous vegetables and exhibits chemopreventive and chemotherapeutic potential against various cancers. However, it is little known about the molecular mechanisms of its antitumor action against ...
- 《Cell Research》 被引量: 2发表: 1997年 Human hematopoietic cells express two forms of the cytokine receptor common γ—chain(γc) Human hematopoietic cells express two forms of the cytokine receptor common γ—chain(γc)细胞分裂素受体人类造血细胞IL-2受体γ链... SHIYUFANG,MARYHILL,等 - ...
The A chain of the plant toxin ricin (RTA) is an N -glycosidase that inhibits protein synthesis by removing a specific adenine from the 28S rRNA. RTA also induces ribotoxic stress, which activates stress-induced cell signaling cascades and apoptosis. However, the mechanistic relationship between...
CELL-LINEHYPOXIACALCIUMBRAINMOTIFErythropoietin (Epo) is the primary regulator of erythropoiesis, controlling the proliferation, maturation, and survival of erythroid progenitor cells. The functions of Epo are mediated through its specific receptor (EpoR) expressed mainly on the surface of erythroid ...
The TLR3 dimeric unit, induced by their binding to dsRNA, further multimerizes laterally along dsRNA, which enables efficient recruitment of adaptor proteins and formation of signalosomes. Full size image TLR3 recruits TRIF as an adaptor protein for signaling, whereas the other TLRs typically recru...
(Cell Signaling Technology, Beverly, MA) at a dilution of 1:250,00 or a 1:1000 dilution of the monoclonal antibody 3F4 derived from a hybridoma cell supernatant made in house, followed by incubation in horseradish peroxidase–conjugated anti-mouse IgG F(ab’) (GE Healthcare Life Sciences, ...
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such... Bjørkøy,Geir,La...