Cell senescence is an integral and increasingly recognised aspect of cellular existence. Ageing and death are part of life! Indoi:10.1002/0470867949.ch8Lee B. JordanDavid J. HarrisonJohn Wiley & Sons, LtdJordan L., Harrison D., 2003. Apoptosis and Cell Senescence. Molecular Biology in ...
Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp. Gerontol. 38, 5–11 (2003). CAS PubMed Google Scholar Giaimo, S. & d’Adda di Fagagna, F. Is cellular senescence an example of antagonistic pleiotropy? Aging Cell 11, 378–383 (2012). CAS ...
Cellular senescence is a process that is mainly designed to eliminate unwanted cells by inducing tissue remodelling. In general, cellular senescence promotes tissue remodelling through three sequential processes: a stable proliferative arrest; a secretory phenotype (SASP) that recruits immune cells and mod...
SASP的成分和强度不同决定于:duration of senescence, origin of the prosenescence stimulus, and cell type SASP可以和外界的微环境通过:juxtacrine NOTCH/JAG1 signaling;release of ROS;cytoplasmic bridges;extracellular vesicles (egexosomes) ) Macromolecular Damage DNA Damage:The first molecular feature associate...
However, when DNA damage is too serious to recover, cell senescence and apoptosis occur [5]. The DNA damage response triggers cell senescence, which ultimately leads to the SASP. During DNA damage-induced senescence, there is increasing evidence that the PIKK family includes a series of ...
Cell senescence, apoptosis and DNA damage cooperate in the remodeling processes accounting for heart morphogenesis Authors:C. I. Lorda-Diez Journal:J Anat (2019): 815-829 Dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest ...
2. Lin, J.J., Milhollen, M.A., Smith, P.G., Narayanan, U., and Dutta, A. (2010). NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, ...
kinetics senescence necrosis apoptosis radiotherapy navitoclax Introduction The presence of fragmented cell-free DNA (cfDNA) within peripheral blood has been recognized for more than 70 years (Mandel and Metais, 1948). Since then, investigation of circulating cfDNA in serum and plasma has seen tremendou...
Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: a short review Biochim. Biophys. Acta, 1783 (2008), pp. 1328-1334 Google Scholar [259] K.U. Frohlich, H. Fussi, C. Ruckenstuhl Yeast apoptosis—from genes to pathways Semin. Cancer Biol., 17 (2007), ...
However, there is another fate for cells after DNA damage: senescence — a state where cells survive, but stop dividing. Senescent cells’ DNA has not been damaged enough to induce apoptosis but is too damaged to support cell division. While senescent cancer cells themselves are unable to proli...