Apoptosis and senescence are two mutually exclusive cell fate programs that can be activated by stress. The factors that instruct cells to enter into senescence or apoptosis are not fully understood, but both programs can be regulated by the stress kinase p38α. Using an inducible system that spe...
Overexpression of WT-DLX3, MT-DLX3 and TR-DLX3 in MC3T3-E1 cells. To abrogate background difference generated by different donors' cells and to further identify whether the novel mutation is a gain- or loss- of function, we constructed plasmids of wild type DLX3, mutant DLX3 (c....
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Biochemical and molecular features of senescence, such as SA-β-Gal, DNA damage signals, and shortened telomeres, have been reported in aging tissues. It has been suggested that the factors determining the balance between senescence and apoptosis upon genotoxic stress are regulated by high mobility ...
Cells were exposed to a single dose of staurosporine, and their caspase activity and cfDNA levels were measured at various times (6–48 h) after treatment. Upon treatment, apoptosis was rapidly induced in all of the examined cell lines (Figure 1B; Figure S1A), followed by cfDNA release ...
(Fig.2B). Senescence and senescence-escape could serve as one mechanism of tumor dormancy and disease recurrence. Specifically, tumor cell senescence can represent a state of dormancy due to cell cycle arrest and apoptosis-resistance, whilst the SASP can establish a dormancy-promoting environment ...
Moreover, the GBM patients with higher risk scores may potentially be more beneficial from drugs that target cell cycle, mitosis, microtubule, DNA replication and apoptosis regulation signaling. Conclusion We identified potential associations between clinical characteristics, TME, stemness, subtypes, and ...
In this regard, the clinical relevance of CD8+ EM1 T-cells in LLV remains to be determined, but they are known to express high levels of granzyme K, which targets viral proteins crucial for replication [35], as well as promoting cell apoptosis. This may be especially relevant in the ...
in the H2O2 group and decreased in the IL/TNF group. There was no difference Inflammatory stress increased the expression of SASP factors. The mRNA expression of SASP factors (MMP-13, ADAMTS-5, MCP-1, and IL-6) was compared by qPCR. Inflammatory stress significantly enhanced the ...
DNA damaging agents such as chemotherapeutics can induce both cellular senescence and apoptosis, another cellular tumor-suppressive mechanism2. Of practical importance, DNA damage induced apoptosis – the primary target of anticancer therapy – has been widely accepted as an important factor in the ...