Senescent cell anti-apoptotic pathways (SCAPs)protect SCs from their own pro-apoptotic SASP. SCs can chemo-attract immune cells and are usually cleared by these immune cells. During aging and in multiple chronic diseases, SCs can accumulate in dysfunctional tissues. SCs can impede innate and ...
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors Aging Cell, 15 (2016), pp. 428-435 CrossrefView in ScopusGoogle Scholar 96. J. Chang, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice ...
cat. no. SG02) for 30 min at room temperature. Cells from adipose tissue were incubated with Fcγ blocker 1:100 (BD, cat. no. 553141) for 5 min at room temperature before staining with cell marker antibodies. The following antibodies were used: BV421-conjugated anti-mouse CD31...
(supplementary fig.4d), indicating these drugs do not kill quiescent melanocytes. These results indicate that nevi-resident melanocytes require pan inhibition of BCL-2 and MCL-1 anti-apoptotic programs to initiate cell death, and this strategy can be carried out non-invasively on skin via topical...
Senescent cells have increase (upregulation) of prosurvival pathways which allow the senescent cell to resist APOPTOSIS. This study selected drugs which targeted the genes which are anti-apoptosis and allow the senescent cell to survive. They show that if turn off the pro survival pathways of sen...
Another crucial feature of senescent cells is apoptotic resistance, which is, in part, attributable to the transcriptional and cap-independent translational elevation of anti-apoptotic B-cell lymphoma 2 (BCL-2) family proteins (BCL-2, BCL-XL and BCL-W) [36]. Senescent cell...
β-catenin, as the key factor of Wnt signaling, was critical in modulating cell differentiation and proliferation [45]. Studies have provided evidence indicating that the upregulation and subsequent translocation of β-catenin to the nucleus can initiate the activation of cellular survival pathways [...
Through a bioinformatics strategy that leveraged proteomic and transcriptomic data, we discovered networks of senescent cell anti-apoptotic pathways (SCAPs) that enable senescent cells to survive despite their own SASP. We verified this role of these networks in senescent cells by using RNA interference...
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell 15, 428–435 (2016). CAS PubMed PubMed Central Google Scholar Bai, L. & Wang, S. Targeting apoptosis pathways for new cancer therapeutics. Annu. Rev. Med. 65, 139–...
(including chemoattractants, remodeling factors)11,12,13,14. The use of transgenicp16-InkAttacmice, which enable systemic elimination of p16-positive senescent cells, and senolytic drugs, which enable senescent cell killing by targeting anti-apoptotic pathways, have demonstrated that senescent cell ...