And yet there is spatiotemporal organization in terms of hierarchical structure of the genome, its coherently moving regions and membrane-less compartmentalization via phase-separated nucleoplasmic constituents. Moreover, the non-equilibrium or activity-driven nature of the nucleus gives rise to emergent...
The computational scalability of this methodology has been tested and results from benchmarking experiments indicate that real-time simulation of a complete bacterial cell will be possible within 10 years. 展开 关键词: mathematical model, agents, flocking, lipid bilayer, cell membrane, discrete ...
It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders studying lipid cell biology from different perspectives to share what questions they are most interested in and what tools they beli...
The chloroplast membranes are highly regulated and biological active regions of the plant cell, which carry numerous essential proteinaceous components, For example, in the thylakoid membrane the photosynthetic apparatus, one of the most life-relevant biological machineries, is located [6]. Schleiff and...
Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon-19-deleted advanced NSCLC mutation David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou …...
Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, and bone. Although a significant progress has been made toward recognizing about the phenotypic characteristics of M
Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells. Cell Stem Cell 20, 177–190.e4 (2017). CAS PubMed Google Scholar Alexandre, C., Baena-Lopez, A. & Vincent, J.-P. Patterning and growth control by membrane-...
Live-cell imaging reagents include both targeted fluorescent proteins and small membrane permeant fluorescent dyes. To enable live-cell imaging experiments, many reagents are designed for time-lapse over several hours or days, while others ar...
into the cell,TIRFmicroscopy provides an unmatched z-resolution which enables the imaging of events occurring in or close to the plasma membrane, e.g., molecule transport to the plasma membrane.TIRFavoids the problem of being overwhelmed by fluorescence signals from molecules deeper inside the cell...
This study aimed to investigate the role of the ubiquitin E3 ligase membrane-associated RING-CH 7 (MARCH7) in bladder cancer cell CSCs. Methods Male BALB/c nude mice aged 4–5 weeks were utilized to generate bladder xenograft model. The expression levels of MARCHs were checked in online ...