MacDonald et al. show that EGF triggers de-sialylation of plasma membrane glycoproteins like integrins in a mechanism that depends on the Na+/H+antiporter NHE1 and the neuraminidases Neu1 and Neu3. Integrins are trafficked to the Golgi and re-sialylated. ...
Brain metastasis (BrM) poses a significant challenge to the prognosis and quality of life for patients with non-small cell lung cancer (NSCLC). Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system (CNS), has been i
For a drug to be absorbed, reach its site of action, and eventually be eliminated, it must cross one or more biologic membrane barriers. Because such barriers to drugs behave similarly, the cell membrane can serve as an example for all. The cell membrane is composed of a bimolecular sheet...
We further compared the freshly isolated LIFR+PDGFRB+cells with single LIFR+PDGFRB+-derived single clones, TM4SF1+CD44+NT5E+cells with their clones, respectively. During the culture of both these two cell types, genes related to extracellular matrix organization, extracellular structure organization a...
1F). Compared to the parental cells (T24 and 253J), decreased MARCH7 expression was also observed in spheres, which have cancer stem-like cells (CSCs) properties (Interleukin 6 signaling maintains the stem-like properties of bladder cancer stem cells)(Fig. 1G). Fig. 1 MARCH7 was a ...
Compared to other cells in the human body, the structure of red cells is relatively simple. A closed membrane is filled with a concentrated solution of hemoglobin—from a mechanical point of view a Newtonian liquid. The shape is discoidal with average values of diameter and thickness of 8 µ...
Microscopic analyses of the cell networks represented in Figure 1C show virtually single cell suspensions at both concentrations of the laminin-containing matrix as compared to gelatin matrix where a network of cell-cell interconnections or spheroids could be distinguished. In addition, PDCs cultured ...
the membrane has evolved to maintain cellular equilibrium, or internal balance, through efficient and tireless transport mechanisms that make the membrane a sort of microscopic customs official, allowing and denying the entry and exit of ions and molecules in accordance with the cell's real-time nee...
And yet there is spatiotemporal organization in terms of hierarchical structure of the genome, its coherently moving regions and membrane-less compartmentalization via phase-separated nucleoplasmic constituents. Moreover, the non-equilibrium or activity-driven nature of the nucleus gives rise to emergent...
b, Heat map of gene expression in CCK–GFP and non-GFP intestinal epithelial cells by single-cell real time quantitative PCR (single cell RT–qPCR). Compared to non-GFP cells (n = 66), CCK–GFP cells (n = 132) overexpress genes associated with synapse formation (Amigo1, Pclo...