It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders studying lipid cell biology from different perspectives to share what questions they are most interested in and what tools they beli...
Brain metastasis (BrM) poses a significant challenge to the prognosis and quality of life for patients with non-small cell lung cancer (NSCLC). Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system (CNS), has been i
cell membrane, i.e., the membrane present inallcells(whether they be the brain cells, fat cells, skin cells, spermatozoa, plant cells or any other cells, because all of these have a universal arrangement in their membranes). However, it must be noted that the neuronal membrane has several...
To examine whether this rearward flow of the plasma membrane can support migration in the absence of any adhesion, we suspended the cells in a liquid. Under these conditions adhesion-dependent mechanisms that have been proposed to explain cell migration cannot operate. We found that optically ...
the retinal layers and were not morphologically distinct from other CD11b+cells. The differences in the localization and appearance of MHCII+cells in these various models of degeneration may reflect differences in the site of infiltration, either across Bruch’s membrane and RPE, or, as in the ...
BioMed Amber Resin: a rigid material for biocompatible applications requiring long-term topical skin or short-term mucosal membrane contact. BioMed Clear Resin: a rigid, transparent material which is also validated in accordance with ISO 18562, allowing for gas pathway applications in healthcare. ...
Visually evoked 3–5 Hz membrane potential oscillations reduce the responsiveness of visual cortex neurons in awake behaving mice. J. Neurosci. 37, 5084–5098 (2017). Article CAS PubMed PubMed Central Google Scholar Lasztóczi, B. & Klausberger, T. Layer-specific GABAergic control of ...
organoids have to exhibit three cell layers—endothelial cells, pericytes and astrocytes to ensure highly selective permeability of substances across this membrane. Showing impermeability to dextran particles ranging from 4 to 70 kDa and with values of transendothelial electrical resistance (TEER) over ...
(Fig.4j). Genes in cluster 6 were enriched for biological processes strongly associated with cAMP-mediated signalling (for example,Plc21Candorb2). Particularly, rutabaga (rut), a membrane-bound Ca2+/calmodulin-activated adenylyl cyclase responsible for the synthesis of cAMP, is highly expressed in...
(Pearsonr = 0.96), and proteomes of whole cells differed from those of nuclei alone, as expected from subcellular proteomics experiments based on biochemical separation18(Extended Data Fig.2a,b). In the bioinformatic enrichment analysis, terms like plasma membrane, mitochondrion, nucleosomes ...