Cell-free fetal DNA testing: a pilot study of obstetric healthcare provider attitudes toward clinical implementation. Prenat Diagn. 2011;31:1070-6.Sayres, L.C.; Allyse, M.; Norton, M.E.; Cho, M.K. Cell-free fetal DNA testing: A pilot study of obstetric healthcare provider attitudes ...
Since the 1960s, there have been numerous attempts to use fetal nucleated cells that have entered into maternal blood for prenatal testing. However, the rarity of such cells has impeded this approach from becoming a clinical reality. Because cell-free tumor DNA has been detected in the plasma...
BACKGROUND: Cell-free fetal DNA (cffDNA) non-invasive prenatal testing (NIPT) is rapidly expanding, and is being introduced at varying rates depending on country and condition. OBJECTIVES: Determine accuracy of cffDNA-based NIPT for all conditions. Evaluate influence of other factors on test perf...
The discovery of cell-free foetal DNA (cffDNA) in maternal circulation in 19971opened a new era in non-invasive prenatal testing (NIPT). cffDNA in the maternal circulation serves as an alternative source of foetal genetic material to chorionic villi or amniocytes which are obtained using invasi...
First-trimester combined screening has a poor positive predictive value (PPV), estimated at approximately 6%,1 and although invasive sampling has recently been reported as carrying low risk of miscarriage,2 these risks are still inherent to the procedure. Cell-free fetal DNA (cfDNA) testing has ...
A method for obtaining fetal cells for diagnostic examination comprises removing detached cells from the uterine cavity and outer surface of the amnionic sac. The cells are then incubated in the presence of a separation antibody which binds preferentially to either fetal cell antigens or maternal ...
Routine testing of fetal Rhesus D status in Rhesus D negative women using cell-free fetal DNA: an investigation into the preferences and information needs ... Routine testing of fetal Rhesus D status in Rhesus D negative women using cell free fetal DNA: an investigation into the preferences ...
The fraction of circulating cell-free fetal (cff) DNA in maternal plasma is a critical parameter for aneuploidy screening with non-invasive prenatal testing, especially for those samples located in equivocal zones. We developed an approach to quantify cff DNA fractions directly with sequencing data,...
there have been numerous attempts to use fetal nucleated cells that have entered into maternal blood for prenatal testing. However, the rarity of such cells has impeded this approach from becoming a clinical reality. Because cell-free tumor DNA has been detected in the plasma of patients with ...
Non-invasive prenatal testing using cell-free fetal DNA in maternal circulation. Clin Chim Acta 2014;428: 44-50.Nilesh, DharajiyaTricia, ZwiefelhoferXiaojun, GuanVach, AngkachatchaiJuan-Sebastian, Saldivar. Noninvasive Prenatal Testing Using Cell-Free Fetal DNA in Maternal Plasma. 2015:, 8.15...