Cell-free fetal DNAPrenatal diagnosisNoninvasive diagnosisAneuploidyThis paper contains a joint position of the PolishEuropean Journal of Obstetrics, Gynecology and Reproductive Biology: An International JournalCell-free fetal DNA testing in prenatal diagnosis:Recommendations of the polish gynecological society...
The fetal fraction, or percentage of total cell-free DNA (cfDNA) in a sample derived from the fetus, can impact NIPT results and profitability.
aCell-free fetal DNA in maternal plasma presents interest as it can possibly serve as a pregnancy associated biomarker. For its quantitation, we investigate the use of fluorescent polymerase chain reaction (PCR) amplification of short tandem repeats (STRs) in pregnancies irrespective of sex. 当它...
The discovery of cell-free foetal DNA (cffDNA) in maternal circulation in 19971opened a new era in non-invasive prenatal testing (NIPT). cffDNA in the maternal circulation serves as an alternative source of foetal genetic material to chorionic villi or amniocytes which are obtained using invasi...
20,21 Previous studies have also demonstrated an association between a low fetal fraction and trisomies 13 and 18, which may be explained by a small placenta leading to reduced fetal DNA in the maternal plasma.22,23 Data suggesting an increased risk for fetal trisomy 21 among low fetal ...
Cell-free fetal DNA (cff-DNA) is a novel promising biomarker that has been applied in various aspects of obstetrical research, notably in prenatal diagnosis and complicated pregnancies. It is easily detected by semi-quantitative PCR for the SRY target gene. It is well recognized that the levels...
ObjectiveTo determine the sensitivity and specificity of circulating cell-free fetal DNA in determining the fetal RHD status and fetal sex. MethodsMaternal blood was collected in each trimester of pregnancy from RhD negative nonalloimmunized women. Whole blood was centrifuged, separated into plasma an...
(3) 40 cases of preeclampsia were positive,concentration of mild preeclampsia was 2.39 times of the normal third-trimester,and concentration of severe preeclampsia was 5.78 times of the normal third-trimester.Conclusion Contect of cell-free fetal DNA in maternal plasma increase as pregnancy advances,...
To the best of our knowledge, this is the first report on this topic, confirming the presence of fetal cell-free DNA from the plasma of a pregnant captive elephant, and demonstrating a new opportunity for non-invasive assessment in fetal sex determination....
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