The prenatal test of cell-free fetal DNA (cffDNA) is also known as noninvasive prenatal testing (NIPT) with high sensitivity and specificity. This study is to evaluate the performance of NIPT and its clinical relevance with various clinical indications. A retrospective analysis was conducted on ...
The fetal fraction, or percentage of total cell-free DNA (cfDNA) in a sample derived from the fetus, can impact NIPT results and profitability.
The use of low molecular weight heparin reduced the fetal fraction and rendered the cell-free DNA testing for trisomy 21 false negative. Ultrasound Obstet Gynecol; e-pub ahead of print 24 March 2017. 25. Taylor-Phillips S, Freeman K, Geppert J, et al. Accuracy of non-invasive prenatal ...
BACKGROUND: Cell-free fetal DNA (cffDNA) non-invasive prenatal testing (NIPT) is rapidly expanding, and is being introduced at varying rates depending on country and condition. OBJECTIVES: Determine accuracy of cffDNA-based NIPT for all conditions. Evaluate influence of other factors on test perf...
there have been numerous attempts to use fetal nucleated cells that have entered into maternal blood for prenatal testing. However, the rarity of such cells has impeded this approach from becoming a clinical reality. Because cell-free tumor DNA has been detected in the plasma of patients with ...
Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.
Since the 1960s, there have been numerous attempts to use fetal nucleated cells that have entered into maternal blood for prenatal testing. However, the rarity of such cells has impeded this approach from becoming a clinical reality. Because cell-free tumor DNA has been detected in the plasma...
Fetal cell-free DNA A major breakthrough in the approach to accurate, noninvasive prenatal screening occurred after the discovery of fetal cfDNA in the maternal serum in 1997.10 Circulating cfDNA fragments are short fragments of DNA found in the blood. During pregnancy, there are cfDNA fragments...
The discovery of cell-free foetal DNA (cffDNA) in maternal circulation in 19971opened a new era in non-invasive prenatal testing (NIPT). cffDNA in the maternal circulation serves as an alternative source of foetal genetic material to chorionic villi or amniocytes which are obtained using invasi...
Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides an alternative to invasive techniques for some heritable disorders. In some countries this testing has transitioned to clinical care, despite the absence of a formal assessment of performance.To document overall test perf...