Sayres LC, Allyse M, Norton ME, Cho MK (2011) Cell-free fetal DNA testing: a pilot study of obstetric healthcare provider attitudes toward clinical implementation. Prenat Diagn 31(11):1070–1076Sayres LC, Allyse M, Norton ME, Cho MK. Cell-free fetal DNA testing: a pilot study of ...
The fetal fraction, or percentage of total cell-free DNA (cfDNA) in a sample derived from the fetus, can impact NIPT results and profitability.
A new type of prenatal screening however, offers parents-to-be a better option. Cell-Free Fetal DNA testing detects chromosomal abnormalities through a simple blood test that is more accurate than current screening tests and can be done earlier in pregnancy—as early as the 10th week, with res...
The discovery of cell-free foetal DNA (cffDNA) in maternal circulation in 19971opened a new era in non-invasive prenatal testing (NIPT). cffDNA in the maternal circulation serves as an alternative source of foetal genetic material to chorionic villi or amniocytes which are obtained using invasi...
Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.
Since the 1960s, there have been numerous attempts to use fetal nucleated cells that have entered into maternal blood for prenatal testing. However, the rarity of such cells has impeded this approach from becoming a clinical reality. Because cell-free tumor DNA has been detected in the plasma...
Forest plot of studies testing fetal sex using cell-free fetal DNA. No significant effect on sensitivity was found with test technique; however, there was a difference in specificity with real-time quantitative PCR (0.999; (95% CI 0.991–1.000) performing better than conventional PCR (0.939; 95...
Abstract. Objective: To review clinical validation or implementation studies of maternal blood cell-free (cf) DNA analysis in screening for aneuploidies
Obstet Gynecol Surv 2016;71(3):146-147 One of the most important technical advances in prenatal care in recent times is analysis of cell-free DNA (cfDNA) in the maternal plasma to screen for fetal aneuploidy. Use of cfDNA screening for aneuploidy was clinically introduced in 2011 in the Uni...
Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis. BMC Res Notes. 2012;5(1):476.Wright CF, Wei Y, Higgins JPT, Sagoo Gs. Non- invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-...