Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.
Cell-free DNA (cfDNA) is an emerging biomarker that already has significant clinical utility. With further development, cfDNA characterization may become a ubiquitous companion modality for diagnosis, prognosis, treatment selection, and recurrence detection for myriad medical conditions. In this chapter, ...
Christian Iseli, PhD2, Liam Brennan3, Magne Osteras, PhD4, Ioannis Xenarios, PhD2, Laurent Farinelli, PhD4 and Bernard Conrad, MD3 Purpose: Cell-free DNA (cfDNA) testing for fetal aneuploidies was broadly implemented for common trisomies and sex-chromosome anomalies (SC...
Yet, cell-free DNA (cfDNA) analysis in healthy individuals comes with substantial challenges such as the lack of large cohort studies addressing the impact of mutations in healthy individuals or the low abundance of cfDNA in plasma. In this study, we aimed to investigate the technical feasibility...
A DNA-based prenatal blood test used to screen pregnancies for Down syndrome and similar chromosome abnormalities in high-risk women has moved a step closer to use in the general pregnancy population. Researchers at Women & Infants Hospital of Rhode Island, a Care New England hospital, have ...
cell-free protein synthesis;chassis;gene circuits;micro-compartments;stochasticity 1. Introduction Fascinated by the emergence of life from non-living matter through billions of years of evolution, scientists began to comprehend and reconstruct how this occurred. Advances in multi-disciplinary research fiel...
comes from the DNA of the cells that form the placenta or perform the anchoring function, not the cells that form the fetus. Therefore, it’s not entirely accurate to use “cell freefetalDNA” when discussing MaterniT21, Harmony, Verifi, or Panorama-style non-invasive prenatal testing. ...
Integrated cell banking and testing services in our cGMP compliant facilities enable the rapid release of cell banks. Learn More Cell Line Characterization Demonstrate that your biologic is free from contaminants with our off-the-shelf biosafety assays. ...
On the molecular level, their cardiotoxic effects origin predominantly from induction of oxidative stress and subsequent increased production of free radicals, which results in mitochondrial dysfunction, DNA damage, cell apoptosis, and electrophysiological disturbances (for review, see Magdy et al. [112]...
remainder of the assay, cells are maintained in fresh medium with free exchange of nutrients and waste products. The cavity of the particles has also been shown to protect cells from damage during FACS droplet-in-air sorting, yielding improved viability for adherent CHO cells48. These aspects ...