Cell-free DNA (cfDNA) is an emerging biomarker that already has significant clinical utility. With further development, cfDNA characterization may become a ubiquitous companion modality for diagnosis, prognosis, treatment selection, and recurrence detection for myriad medical conditions. In this chapter, ...
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Obstet Gynecol Surv 2016;71(3):146-147 One of the most important technical advances in prenatal care in recent times is analysis of cell-free DNA (cfDNA) in the maternal plasma to screen for fetal aneuploidy. Use of cfDNA screening for aneuploidy was clinically introduced in 2011 in the Uni...
cell-free DNAfirst trimester pregnancyNIPTprenatal screeningObjective: First, to assess what was the uptake of cell free DNA (cfDNA) testing after a combined test and the maternal and fetal factors that influenced this decision, and second, to assess the uptake and factors that influence the ...
DNA molecule: cytosine, guanine, adenine, and thymine—C, G, A, and T, for short. Specific sequences of these bases, known asgenes,form codes that contain all of an organism's genetic information. When other components of a cell "read" this code, they produce proteins, the building ...
Cell-free DNA noninvasive prenatal screening for trisomies 21, 18, and 13 has been rapidly adopted into clinical practice. However, previous studies are limited by a lack of follow-up genetic testing to confirm the outcomes and accurately assess test performance, particularly in women at a low ...
Bronchial washing fluid, obtained by lavage with saline after tumor biopsy or brushing, and the supernatant of bronchial washing fluid are thought to contain cell-free DNA that would be potentially applicable for EGFR testing.METHODS: From among patients with suspected adenocarcinoma or non-small ...
A new type of prenatal screening however, offers parents-to-be a better option. Cell-Free Fetal DNA testing detects chromosomal abnormalities through a simple blood test that is more accurate than current screening tests and can be done earlier in pregnancy—as early as the 10th week, with res...
The E. coli cell-free protein synthesis system is fundamentally based on the Zubay system (Zubay, 1973), which uses the E. coli cell extract. Transcription from DNA to mRNA and translation from mRNA to protein are performed in a coupled manner. We use an exogenous RNA polymerase from T7...
Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive cancer detection and monitoring, organ transplantation, prenatal genetic testing and pathogen detection. While cfDNA samples can be obtained using a broad variety of approaches, there is an urgent need to stand...