The compositions can include a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant ...
Obstet Gynecol Surv 2016;71(3):146-147 One of the most important technical advances in prenatal care in recent times is analysis of cell-free DNA (cfDNA) in the maternal plasma to screen for fetal aneuploidy. Use of cfDNA screening for aneuploidy was clinically introduced in 2011 in the Uni...
cell-free DNAfirst trimester pregnancyNIPTprenatal screeningObjective: First, to assess what was the uptake of cell free DNA (cfDNA) testing after a combined test and the maternal and fetal factors that influenced this decision, and second, to assess the uptake and factors that influence the ...
Here, we present an integrated experimental and computational system for the accurate and affordable detection of cancer. It consists of (1) a cost-effective experimental assay, named cell-free DNA Methylome Sequencing (cfMethyl-Seq), for genome-wide methylation profiling of cfDNA, and (2) a co...
Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.
Cell-free DNA noninvasive prenatal screening for trisomies 21, 18, and 13 has been rapidly adopted into clinical practice. However, previous studies are limited by a lack of follow-up genetic testing to confirm the outcomes and accurately assess test performance, particularly in women at a low ...
Cuckle H. Strategies for implementing cell-free DNA testing. Clin Lab Med. 2016;36(2):213-226. doi:10.1016/j.cll.2016.01.010PubMedGoogle ScholarCrossref 22. Cuckle H, Benn P, Pergament E. Maternal cfDNA screening for Down syndrome—a cost sensitivity analysis. Prenat Diagn. 2013;33(...
Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive cancer detection and monitoring, organ transplantation, prenatal genetic testing and pathogen detection. While cfDNA samples can be obtained using a broad variety of approaches, there is an urgent need to stand...
Are special read alignment strategies necessary and cost-effective when handling sequencing reads from patient-derived tumor xenografts?Tso K,et al.BMC Genomics.2014 Dec 23. 02无创检测 Amplification-free sequencing of cell-free DNA for prenatal non-invasive diagnosis of chromosomal aberrations.Karlsson ...
Cell-free DNA (cfDNA) is a promising, minimally invasive biomarker that may originate from cell lysis, apoptosis, necrosis, and active release of DNA fragments into circulation4,5,6,7. In healthy individuals, cfDNA is predominantly of hematopoietic origin8. In cancer patients, cfDNA includes DNA...