When cells are stimulated by injury, the cell cycle cannot proceed normally and arrest at a certain stage. This phenomenon is called cell cycle arrest. Renal tubular epithelial cells of AKI patients usually have cell cycle arrest in G1 and/or G2 phases, which indicates that the expression ...
Cell cycle arrest refers to the process in eukaryotic cells where DNA replication is halted upon detection of damage, allowing for repair before mutations occur. This mechanism helps prevent irreversible interference with replication and maintains genomic integrity. ...
cell cycle arrest细胞周期阻滞(Cell Cycle Arrest)是指细胞在细胞周期中不能顺利从一个阶段进入下一个阶段的现象。这种阻滞是细胞周期调控中的重要机制,对于维持细胞稳态、基因稳定性和防止疾病发生具有重要意义。 一、细胞周期阻滞的定义与意义 细胞周期阻滞通常由于细胞内外信号的缺乏或...
How cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid peroxidation
Statin, a marker of cell cycle arrest, is overexpressed during the early phase of delayed NMDA toxicity in hippocampal cell cultures. 来自 dx.doi.org 喜欢 0 阅读量: 30 作者: Alonso,R 摘要: Statin is a 57-kDa protein exclusively expressed in nuclei of nonproliferating mammalian cells. Recent...
DNA replication, cell cycle progression and the targeted gene repair reaction Authors: Engstrom JU, Kmiec EB. Journal: Cell Cycle (2008): 1402 Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway Authors: ...
cell-cycle arrest (This response can also be elicited by inhibiting or altering genes involved in telomere maintenance ) Type2 oxidative DNA damage at telomeric G-reach repeats telomere-associated foci (TAFs), can exist at telomeres (irrespective of telomere length or shelterin loss ) ...
We previously demonstrated that forced expression of p57, which induces cell cycle arrest at either G1 or G2 phase, in rapidly dividing NPCs of the developing mouse neocortex suppresses neuronal differentiation and increases the fraction of NPCs positive for the undifferentiated state marker Sox2 in ...
Treatment of PC-3 cells with G-1 induced cell-cycle arrest at the Gphase and reduced the expression of G-checkpoint regulators (cyclin-A2, cyclin-B1, cdc25c, and cdc2) and phosphorylation of their common transcriptional regulator NF-YA in PC-3 cells. With extensive use of siRNA-knockdown ...
1. 细胞周期受抑制 ...们产生突变. 1.2. 细胞对DNA损伤的反应:细胞周期受抑制(cell-cycle arrest) 死亡 (apoptosis) 除DNA损伤物外,细胞必须 … wenku.baidu.com|基于 1 个网页 2. 细胞周期阻滞 DNA损伤发生后,由蛋白精氨酸N端甲基化转移酶5(PRMT5)介导的p53精氨酸甲基化能够导致细胞周期阻滞(cell-cycle ...