Fetal wound scarless healing is known as an ideal method of healing. This method is completed by some combined actions within cells such as adhesion molecules, cytokines under the precise control of genes, and the ECM [35]. ECM synthesis and remodeling are essential for wound healing; recent s...
Epidermal differentiation is a complex process that requires the regulated and sequential expression of various genes. Most fused-type S100 proteins are expressed in the granular layer and it is hypothesized that these proteins may be associated with cornification and barrier formation. We previously id...
In subject area: Biochemistry, Genetics and Molecular Biology NCAMs are a family of cell surface glycoproteins that accomplish Ca2+-independent adhesion, either through homophilic or heterophilic binding, between molecules on neighboring cells or between cell and ECM proteins. ...
Cadherins constitute a family of transmembrane cell-cell adhesion proteins involved in morphogenesis, development and cancer (25). Classical cadherins are the gatekeepers of AJ maintenance by linking their extracellular interactions to internal cellular elements through α-catenin, β-catenin and p120-...
For instance, the transcriptional repressor PRDM1 (also known as BLIMP1) has been reported to play a versatile role in controlling cell fate decisions in developing embryos and adult tissues61. Our results showed that PRDM1 regulated 98 target genes (37 were repressed and 61 were activated, ...
Exosomes, which are extracellular vesicles of endoplasmic origin with a diameters of 30–150 nm, are secreted by cells [6]. Exosomes contains various biologically active molecules, including nucleic acids and proteins, which play a crucial role in intercellular communication [7,8]. Importantly, exos...
Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light). Together, these pathways form an extensive communication network that regulates basic c
Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of neutrophils on adaptive immunity. Exogenous cytokines or cytokines produced in an autocrine manner as...
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. Thus, lysosomes ...
Here, to discover novel therapeutic targets, we present an unbiased loss-of-adhesion CRISPR-Cas9 knockout screening method to identify proteins involved in BCR-controlled integrin-mediated adhesion. Illustrating the validity of our approach, several kinases with an established role in BCR-controlled ...