4 Test Cell Adhesion-Promoting Activity of Laminin Testing the capacity of laminin to mediate cell adhesion follows the same protocol as for testing cell adhesion-promoting activity of any other extracellular m
In subject area:Biochemistry, Genetics and Molecular Biology NCAMs are a family of cell surface glycoproteins that accomplish Ca2+-independent adhesion, either through homophilic or heterophilic binding, between molecules on neighboring cells or between cell and ECM proteins. ...
Epidermal differentiation is a complex process that requires the regulated and sequential expression of various genes. Most fused-type S100 proteins are expressed in the granular layer and it is hypothesized that these proteins may be associated with cornification and barrier formation. We previously id...
For instance, the transcriptional repressor PRDM1 (also known as BLIMP1) has been reported to play a versatile role in controlling cell fate decisions in developing embryos and adult tissues61. Our results showed that PRDM1 regulated 98 target genes (37 were repressed and 61 were activated, ...
around a wound or bone marrow motivated through macrophages are transformed into myofibroblasts. Myofibroblasts are identified as contractile cells and play a remarkable role in the closure of the wound [31]. Both fibroblasts and myoblasts synthesize and deposit ECM proteins, predominantly in the form...
Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light). Together, these pathways form an extensive communication network that regulates basic c
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. Thus, lysosomes ...
Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of neutrophils on adaptive immunity. Exogenous cytokines or cytokines produced in an autocrine manner as...
Crml also mediates the transport of key neuroprotectant proteins that may be useful in neurodegenerative diseases including Parkinson’s disease (PD), Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS). For example, by (1) forcing nuclear retention of key neuroprotective regulators such as...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital ma