Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.Matthew B...
Synaptically localized cell adhesion molecules (SAMs), are multifunctional molecules that coordinate different aspects of synaptic development and function through specialized signalling or protein–protein interaction motifs. Neurexin–neuroligin signalling has a role in the development of pre- and postsynaptic...
Cell adhesion molecules are critical components of communication among cells. They mediate the contact between cells as well as between cells and the extracellular matrix, thus maintaining the integrity of the tissues. A majority of adhesion molecules can be grouped into integrins, cadherins, selectin...
Cell–cell adhesions are inevitably exposed to mechanical forces. A landmark paper by Yonemura et al. identified how tension alters molecular function of the cadherin adhesion apparatus. Its legacy lies in the many on-going efforts to understand how mechanical force is used in cell–cell communicat...
adhesion molecules, governing proper cell-cell and cell-matrix interactions, respectively. In contrast to normal tissues, malignant tumors are characterized by a disruption of these processes. Thus, cell adhesion molecules have been shown to be expressed and/or to function abnormally in many types...
3. Boucard, A.A., Maxeiner, S., and Su ̈ dhof, T.C. (2014). Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing.J. Biol. Chem.289, 387–402.
Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synapt...
Cell adhesion molecules function by forming specific protein–protein or protein– carbohydrate bonds at the cell surface to mediate cell interactions. In addition, cell adhesion molecules or their receptors often form direct associations with cytoplasmicbased proteins, which allow these complexes to ...
Overview of Structure and Function As with allcell adhesion molecules, the integrins are transmembranecell surface proteins. Unlike the other families of cell adhesion molecules, the integrins areheterodimers, consisting of noncovalently associated α andβ subunits, generally of 150 and 100 kDa, respec...
The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules During the past year considerable progress has been made in our understanding of cadherin structure and function. Recent research has concentrated on sever... GB Grunwald - 《Current Opinion in Cell Biology》 ...