This review will update the current understanding of the complex mechanism behind yeast flocculation. Moreover, modern technologies to measure the forces involved in single carbohydrate-lectin interactions, are discussed. The Flo1 protein has been extensively described as the protein responsible for ...
We show that the matricellular protein CCN1 (also known as CYR61; cysteine-rich protein 61), which is dynamically expressed at sites of wound repair, can induce fibroblast senescence by binding to integrin α6β1 and the heparan sulphate proteoglycans (receptors involved in cell adhesion). C...
For example, glycans are known to be involved in cell adhesion, molecular trafficking and clearance, receptor activation, signal transduction, and endocytosis1. Alterations in glycosylation have also been implicated in many human diseases including the development and progression of cancer1, and ...
One of a large class of complex organic chemical compounds that are essential for life. Proteins play a central role in biological processes and form the basis of living tissues. They consist of long, looping or folding chains of smaller compounds called amino acids. Enzymes, antibodies, and he...
LFA-1 is a beta2 integrin involved in T cell activation and adhesion (Ford and Larsen, 2009) through binding to its ligand ICAM1. LFA-1 is a heterodimer consisting of an alpha chain (CD11a/αL) and a beta chain (CD18/β2). ICAM1 binds to an inserted domain (I domain) located ...
n is the number of pentamer repeat units along the polypeptide chain; and X can be any amino acid except proline), have been shown to trigger complex coacervation process by alternating temperature or X species (e.g., lysine (Lys)), resulting in adhesion behavior [22], [23], [24], ...
Through the use of specific class I pharmacological inhibitors and specific genetic silencing, we revealed the role of HDAC1–2 in controlling α5β1 Integrin-mediated EOC cell adhesion to MCs. Of note, MS-275 was demonstrated to perturb the expression of actin-interacting proteins such as Talin...
(Fig.4c). Meanwhile, the downregulated genes were mainly involved in proteolysis, oxidation-reduction process, and serine hydrolase activity, etc. (Fig.4d). The relevant top-enriched up-KEGG pathways indicated that the Gel-co-MGFF enhanced cell adhesion and proliferation (Focal adhesion, PI3K-Akt...
10). Translocation of proteins involved in cell division is highly expected because the process involves the formation of mitotic structures such as the mitotic spindle and the cytokinetic bridge, which are seen only in certain stages of the cell cycle. Proteins involved in transcriptional regulation...
such as intercellular adhesion molecules (ICAMs), vascular adhesion molecule (VCAM), platelet-endothelial adhesion molecule (PECAM), and junction adhesion molecule (JAM). These last two proteins are involved in homophilic contact (JAM–JAM and PECAM–PECAM) organization, whereas ICAMs and VCAM serve...