这些祖细胞分为两个亚群:髓系衍生的pre-cDC2和淋巴系衍生的pDC样细胞。研究揭示了cDC2在起源、转录组谱、表型和组织分布上的多样性,突显了不同谱系祖细胞对成熟cDC2特性的影响,为理解免疫细胞发育和功能多样性提供了新的视角。 SUMMARY Conventional dendritic cells (cDC) are antigen-presenting cells comprising cDC1...
然而，这些类pDC的细胞亚群的性质、功能和发育特性以及它们与先前描述的DC亚群之间的相互关系尚不清楚。来自美国NIH的Roxane Tussiwand团队在Science Immunology上发表题为 pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells 的文章。本文发现类pDC的细胞在所有组织中都有，是循环cDC前...
2023年10月20日,肖能明教授课题组在Nature Communications杂志上发表了题为“The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells”的研究论文,揭示了Zeb1-microRNA-96/182-cybb通路在cDC1抗原交叉递呈中的重要调控作用以及Zeb1在脾脏cDC1稳态维持中的必要性。 ASFV引...
这些祖细胞分为两个亚群:髓系衍生的pre-cDC2和淋巴系衍生的pDC样细胞。研究揭示了cDC2在起源、转录组谱、表型和组织分布上的多样性,突显了不同谱系祖细胞对成熟cDC2特性的影响,为理解免疫细胞发育和功能多样性提供了新的视角。 SUMMARY Conventional dendritic cells (cDC) are antigen-presenting cells comprising cDC1...
树突状细胞(Dendritic cells,DCs)作为体内功能最强的抗原提呈细胞,通过提呈抗原触发初始T细胞免疫应答并分泌IL.12等细胞因子的方式在机体抗TB免疫应答中发挥关键作用,是联系天然免疫和获得性免疫应答的桥梁。然而,DCs是由许多表型和功能不同的亚型组成的高度异质性群体,稳态时小鼠脾脏DCs主要包括浆细胞DC(plasmacytoid DCs...
Data are pooled biologically independent samples from two independent experiments (n = 6 for cDC1, cDC2, plasmacytoid dendritic cells (pDC) and B cells from Xcr1+/+ R26LSLYFP/+ mice, n = 7 for cDC1, cDC2, pDC and B cells from Xcr1Cre/+ R26LSLYFP/+ mice, and n = 4 for all ...
pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during immune responses, ranging from initial viral control through the production of type I interferons to antigen presentation. However, re...
pDCprognosis factorObjectives Dendritic cells play a pivotal but still enigmatic role in the control of tumor development. Composed of specialised subsets (cDC1s, cDC2s, pDCs), DCs are critical in triggering and shaping antitumor immune responses. Yet, tumors exploit plasticity of DCs to subvert ...
Activated human pDCs attract CD8+T cells, CD56+T cells, and γδ T cellsin vitro • cDC2- and pDC-based cancer vaccines attract lymphocytes in melanoma patient skin Summary Plasmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (cDC2s) are currently under evaluation for ...
近日,来自德国慕尼黑大学附属医院的Florian Gaertner团队在Nature期刊发表题为Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis(浆细胞样树突状细胞调控巨核细胞生成稳态)的文章。研究人员揭示了浆细胞样树突状细胞(pDCs)通过监测骨髓中的凋亡...