Trends in ImmunologySegura E, Amigorena S. Inflammatory dendritic cells in mice and humans . Trends Immunol (2013) 34 ( 9 ):440–510.1016/j.it.2013.06.001 [ Cross Ref ]Segura E, Amigorena S (2013) Inflammatory dendritic cells in mice and humans. Trends Immunol 34(9):440–445. : 10....
In contrast, OP952hematogenic stromal cells stably expressing membrane-bound FLT3L (OP9_F) were less efficient than MS5_F in driving cDC differentiation (Fig.1c). Besides, MS5_F also promoted the appearance of CD123+CD303/4+cells resembling either pDCs or pre/AS-DCs12,20(Supplementary F...
Several DC subpopulations have been defined,2, 3 a fact that often seems bewildering to the nonexpert, especially when the markers used to define DCs differ between humans and mice. DCs are broadly divided into myeloid dendritic cells (mDCs), usually now referred to as conventional dendritic ce...
dendritic cells in allergic sensitization in humansdendritic cells as drug targets in allergic diseasesThe lung contains many subsets of dendritic cells (DCs) that are distributed in various anatomic compartments. These cells possess all the machinery to take up and process antigen into the major ...
However, increasing exposure through advances in medical applications orthodontic/orthopedic metal implants, vanadium-containing drugs and environmental exposure have raised questions on the influence of vanadium on the immune system. As initiators of the adaptive immune response, dendritic cells (DC) are...
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have numerous shared characteristics between mice and humans. Human counterparts of mouse DC progenitors have been identified by their shared transcriptional signatures and developmental potential. New findings continue to ...
Kavousanaki M, Makrigiannakis A, Boumpas D, Verginis P: Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy. Arthritis Rheum. 2010, 62: 53-63. 10.1002/ar...
In this paper we will review the role of DCs in inflammation and autoimmunity in human ageing and will highlight the observations that DCs from aged humans display impairment in their capacity to uptake apoptotic cells, and paradoxically induce proinflammatory response and increased reactivity to self...
Age-related increases and decreases have been described in cortical dendritic neuropil. Here, we examine age-related changes in the basilar dendrites of supragranular pyramidal cells in human superior temporal gyrus (i.e., Wernicke's area) of left and right hemispheres. Tissue was obtained from ...
Plasmacytoid dendritic cells(pDCs) function as sentinels against viral infection in humans by producingabundant amounts of Type-I and Type-III interferons as well as other cytokines. Detection of viral nucleic acids remains the major initiating factor forinterferon and cytokine production in pDCs. Alth...