Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subsets in aged subjects; nevertheless, their ...
In vivo description of dendritic cells in human renal cell carcinoma.HumansDendritic CellsCarcinoma, Renal CellKidney NeoplasmsAntigens, CDPurpose Dendritic cells (DCs) are efficient and effective antigen-presenting cells that play a major role in initiating the primary immune response. They are the ...
In contrast, OP952hematogenic stromal cells stably expressing membrane-bound FLT3L (OP9_F) were less efficient than MS5_F in driving cDC differentiation (Fig.1c). Besides, MS5_F also promoted the appearance of CD123+CD303/4+cells resembling either pDCs or pre/AS-DCs12,20(Supplementary F...
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have numerous shared characteristics between mice and humans. Human counterparts of mouse DC progenitors have been identified by their shared transcriptional signatures and developmental potential. New findings continue to ...
However, increasing exposure through advances in medical applications orthodontic/orthopedic metal implants, vanadium-containing drugs and environmental exposure have raised questions on the influence of vanadium on the immune system. As initiators of the adaptive immune response, dendritic cells (DC) are...
Dendritic cells (DCs) in the pregnant uterine mucosa have been poorly characterized, although they are likely to regulate to both placental trophoblast cells and . In this study an HLA-DR+, CD11c+ - (CD3-, -, CD56-, -) population has been identified by three-color flow cytometry. The ce...
Although T-cell-defined tumor antigens have recently been identified in several tumors, human neoplastic cells are considered to be poorly immunogenic. The development of clinical approaches to the immunotherapy of human tumors thus requires the identification of effective adjuvants. Dendritic cells (DC...
Dendritic cells (DC) have recently emerged as key modulators of this immunopathological cascade, as supported by studies in humans and experimental disease models. In one such model, experimental autoimmune encephalomyelitis (EAE), CNS microvessel-associated DC have been shown to be essential for ...
LCs are bone-marrow–derived dendritic cells that migrate to and reside in the epidermis, where they sample antigen and constitutively migrate out of the skin in low numbers to the DLNs [1]. From:Immunology and Allergy Clinics of North America,2003 ...
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193, 233–238 (2001). CAS PubMed PubMed Central Google Scholar Steinman, R. M., Turley, S., Mellman, I. & Inaba, K. The induction of tolerance by dendritic ...