In group I with HAI, the preoperative median cytotoxic T-lymphocyte (CD8-T-cell) level was found to be below normal, and remained very low throughout the study period. In addition, the median and interquartile CD8 T-cell range (358cells/L; 304424cells/L) were twice as low compared to...
Science|探索HIV疫苗失败原因,深度分析CD8+T细胞功能 美国国立卫生研究院国家过敏和传染病研究所免疫调节实验室Mark Connors团队在顶级期刊Science(IF= 63.832)上发表关于HIV疫苗的最新研究成果:HIV Vaccines Induce CD8+T Cells with Low Antigen Receptor Sensitivity,探索了HIV疫苗诱导的特异性CD8+T细胞的功能,以期能够解...
2023年12月14日,美国国立健康研究院Mark Connors团队在Science上在线发表了题为HIV Vaccines Induce CD8+ T Cells with Low Antigen Receptor Sensitivity的研究论文,详细研究了疫苗诱导的 HIV 特异性 CD8+ T 细胞的功能。 研究人员首先发现Merck Ad5/HIV疫苗虽然在外周血中能够诱导CD8+ T 细胞扩增,但细胞毒性能力(...
为了证明这点，来自美国埃默里大学医学院的Kelsey B. Bennion团队在Science Translational Medicine杂志上发表了一篇题为 FcγRIIB expressed on CD8+ T cells limits responsiveness to PD-1 checkpoint inhibition in cancer 的文章，他们描述了FcγRIIBpos和FcγRIIBneg CD8+T细胞对是否含Fc片段的检查点抑制剂的反...
研究发现替比夫定可抑制CHB患者外周血病毒特异性Th17细胞水平和IL-22的分泌[7],调节性T细胞(regulatory T cells,Treg)水平亦降低,病毒特异性Treg/Th17细胞比例的显著下降可预测HBeAg血清学转换[8-9]。在使用阿德福韦酯抗病毒治疗过程中,...
Low-Affinity Memory CD8+T Cells Mediate Robust Heterologous Immunity Heterologous immunity is recognized as a significant barrier to transplant tolerance. Whereas it has been established that pathogen-elicited memory T cells... Scott,M.,Krummey,... - 《Journal of Immunology》 被引量: 11发表: 201...
大多数效应细胞寿命都不长,在清除感染或肿瘤细胞后出现凋亡。小部分(5-10%)以不同的表型作为长寿命记忆性细胞存活下来;组织驻留记忆T细胞(tissue resident memory T cells, Trm)存在于发起原发反应的组织中、中枢记忆T细胞(Tcm)在次级淋巴组织中循环,效应记忆T细胞(Tem)在非淋巴...
The interaction of T cell receptors (TCRs) on T cells with MHC I-peptide complexes on cancer cells elicits the cytotoxic activity of CD8 +T cells. Here we analyze how the strength of this interaction, or T cell avidity, shapes the exhaustion of CD8 +TILs and dictates anti-tumor immunity...
cells in absence of the chronic environment leads to upregulation of new transcriptional modules. CD45.1+TCR-transgenic P14 CD8 T cells recognizing the LCMV-derived gp33–41peptide were adoptively transferred into CD45.2+hosts one day prior infection with a low (200 ffu) or high (2 × ...
今天和大家分享一篇于2022年10月在Cancer Letters上发表的一篇影响因子9.756的文章"IFNγ− IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human hepatocellular carcinoma",作者采用ScRNA-SEQ技术,研究聚焦了尚未全阐释清楚的Tc 17细胞亚群,从Tc 17细胞亚群的基因、分子以及功能上揭示...