CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate antitumour responses; however, most patients wit...
近期，来自荷兰University of Groningen的Elisabeth G. E. de Vries研究组在Nature Medicine上发表题为Whole-body CD8+T cell visualization before and during cancer immunotherapy: a phase 1/2 trial的文章，通过设计制备靶向CD8a的指示抗体，展示了肿瘤免疫治疗1/2的临床数据，以及CD8+T的动态分布特征。为了具体...
CD8 T cell deficiency in a 25 y. Old male with bronchiectasisWe describe a 13-year-old boy with a very late presentation of vertically transmitted HIV-1 infection. The mother, an intravenous drug user before pregnancy, was diagnosed with AIDS in 1987 when the boy was 6 years old. HIV ...
as evidenced by observations that tumor-restricting effect of endogenous or adoptively transferred CD8+T cells was enhanced by intrinsic Rig-I deficiency or inhibition, with the increased accumulation, survival, and cytotoxicit...
苏州大学附属第一医院核医学科研究生贾童童分享了《癌症免疫治疗前和治疗期间全身CD8+ T细胞可视化研究(1/2期试验)》的研究文献。该篇文献于2022年12月发表在Nature Medicine(IF = 87.241)上,原文标题是《Whole-body CD8+T cell vis...
MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice Yuanyue Zhang Zhi Yang Qi Yang Journal of Neuroinflammation(2025) Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy ...
作者进一步在 MKN45 细胞的上清液中培养 CD8+ T 细胞,结果诱导了 CD8+ T 细胞的凋亡和功能障碍,而牛磺酸的添加则阻止了 T 细胞的死亡并增加了细胞因子的产生(图 3I)。 由于牛磺酸的摄取在 GC 细胞和 CD8+ T 细胞中都主要由 SLC6A6 介导,作者推测 GC 细胞通过过表达 SLC6A6 与 CD8+ T 细胞竞争牛磺酸。
近日，中科院上海生物化学与细胞生物学研究所王红艳的团队与上海大学魏滨教授的团队合作，在PNAS上发表题为LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens的文章。 第一作者刘畅博士（同济大学附属第十人民医院）通过免疫共沉淀联合蛋白质质谱等实验，发现LRC...
In vitro, IFN-[gamma] enhanced MMP-2 and MMP-9 gelatinolytic activities in macrophage and/or vascular smooth muscle cells.Conclusion: The vasculoprotective effects of CD8+ T-cell deletion in a mouse CaCl2-induced AAA model were likely attributable to, at least in part, the attenuation of ...
CD8+ T-Cell Dysfunction due to Cytolytic Granule Deficiency in Persistent Friend Retrovirus Infection immer S, Messer RJ, Hasenkrug KJ, Dittmer U (2005) CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection... G Zelinskyy,SJ Robertson,S Schimmer,....