CD8 cells remained committed to their initial dead target for hours, accumulating TCR signals that sustained secretion of soluble antiviral factors. These data indicate that high-avidity CD8+ T-cells execute an antiviral program in the precise location where antigen has been sensed: CTL effector ...
Redefining PD1 as a guardian of stem-like T cells A preprint by Hor et al. shows that PD1 signalling regulates the maintenance of a high-affinity, stem-like T cell subset in tumour-draining lymph nodes. Matthew Jackson Eileen E. Parkes Research Highlights25 Nov 2024 Nature Reviews Immunolo...
We describe a high-dimensional, tetramer-associated T cell antigen receptor (TCR) sequencing (TetTCR-SeqHD) method to simultaneously profile cognate antigen specificities, TCR sequences, targeted gene expression and surface-protein expression from tens of thousands of single cells. Using human ...
原名:Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells 译名:在结直肠癌中肠道罗斯拜瑞氏菌产生的丁酸通过激活细胞毒性CD8+T细胞来增强抗PD-1治疗的疗效 期刊:Gut IF:24.5 发表时间:2023.07 通讯作者:于君,黄曦 通讯作者单位:香港中文大...
PD-1+ Tim-3+ CD8+ T cells are enriched for within the central T (TCM) cell subset, with high proliferative activity and CD127 expression. Co-expression of PD-1 and Tim-3 on CD8+ T cells is associated with increased anti-atherogenic cytokine production as well as decreased pro-...
A pathogenic crosstalk between epithelial and immune cells underpins the aberrant immune and epidermal responses seen in psoriasis. Data from a novel mouse model of psoriasiform skin inflammation not only highlight the importance of the interplay between keratinocytes, targets of genetic manipulation, and...
撰文| 小飞飞 点评 | 郭心怡、董晨(清华大学) 责编 | 兮 急性感染中,CD8+初始T细胞在接受抗原刺激之后,可分化为CD8+效应T细胞(effector CD8+ T cells, TEFF)。如果抗原被清除,一部分的TEFF会持续存在,形…
High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. To investigate the effect of HIV-specific CD8+ T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8+ T c......
今天和大家分享一篇于2022年10月在Cancer Letters上发表的一篇影响因子9.756的文章"IFNγ− IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human hepatocellular carcinoma",作者采用ScRNA-SEQ技术,研究聚焦了尚未全阐释清楚的Tc 17细胞亚群,从Tc 17细胞亚群的基因、分子以及功能上揭示...
Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. Immu- nity ... K Fraser,J Schenkel,S Jameson,... - 《Immunity》 被引量: 81发表: 2013年 Notch1-induced delay of human hematopoietic progenitor cell ...