嵌合抗原受体T细胞(chimeric antigen receptor T cell,CAR-T)疗法目前已应用于血液肿瘤的治疗,前期研究发现CD74在白血病患者白血病干细胞中高表达,为了探索其对白血病细胞的杀伤作用,通过CD74 CAR表达载体的构建、慢病毒载体的包装及T细胞的感染,制备CD74 C...
thymic epithelial cells (TECs)Thymic epithelial cells (TECs) are indispensable for T cell development, T cell receptor (TCR) repertoire selection, and specific lineage differentiation. Medullary thymic epithelial cells (mTECs), which account for the majority of TECs in adults, are critical for ...
CD74别名:LN2, HLA-DR-associated invariant chain概述:II型膜蛋白信号定位:胞质、胞膜在病理学中的应用:不典型纤维黄色瘤(-)与恶性纤维组织细胞瘤(+)的鉴别。 B cell marker (not commonly used) 商品化试剂(排名不分先后,本网站对抗体质量不负责!)公司 克隆号 即用型(ml) 原液(ml) 基因科技 LN2 /...
cell surface forantigen presentationto T-cells[135]. Besides aiding peptide presentation, CD74 has been shown to function as a signaling molecule. By using mAbs against CD74 in was shown that a directsignaling pathwayinvolving nuclear factor-κB resulted in maturation of B-cells[136]. CD74 is...
is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant...
intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 相关产品 免疫组织化学 Secondary Antibodies 同型对照 IHC封片剂...
CD74 is a cell membrane high-affinity receptor for macrophage migration inhibitory factor (MIF), D-dopachrome tautomerase (D-DT/MIF-2) and bacterial proteins. CD74 also regulates T-cell and B-cell developments, dendritic cell (DC) motility, macrophage inflammation, and thymic selection. The act...
CD74 (HLA class II histocompatibility antigen gamma chain isoform b), is a transmembrane protein (on antigen presenting cells) which is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and...
Immune cell infiltration analysis Correlations between the copy number variation (CNV) of CD74 and the abundances of six types of tumor-infiltrating immune cells (TIICs) (B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells) were explored using the ...
应用范围WB,IHC 基因名称CD74 克隆号OTI1G10 抗体来源Mouse 抗体类型IgG1 免疫原Full length human recombinant protein of human CD74(NP_001020330) produced in HEK293T cell. 实际分子量33.3KD 成分PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. ...