嵌合抗原受体修饰的T细胞;CD74;急性髓系白血病;白血病干细胞 白血病干细胞(leukemia stem cell,LSC)是白血病复发难治的重要根源之一,其作为少数具有自我更新潜能并抵抗化疗的一群白血病细胞,长期的自我更新能力可驱动克隆生长。LSC表现出特定的表型,特别是在...
肝干细胞( hepatic stem cell,HSC) 又称肝祖细胞,是肝细胞大片坏死时最早的补充与修复细胞源, 也被认为是未来肝细胞移植治疗终末期肝病最有前途的细胞源之一[2-4]。 但由 于HSC 的特异性标志物尚不明确, 且正常情况下肝组织中 HSC 数量极少, 极大地限制了 HSC 的分离与应用[4]。 本研究通过改进的胶原酶...
Cancer stem cellsThe 纬 subunit of the major histocompatibility complex (MHC) class II complex, CD74, is overexpressed in a significant proportion of metastatic breast tumors, but the mechanistic foundation and biologic significance ...
原文出处 Borrelli MR, Patel RA, Adem S, et al. The antifibrotic adipose-derivedstromal cell: Grafted fat enriched withCD74+adipose-derived stromal cellsreduces chronic radiation-induced skin fibrosis.Stem Cells TranslMed. ...
These include anatomically defined niches for hematopoietic stem cells [102,103], and for B cell development [104]. The BM harbors dendritic cells (bmDC) that function as myeloid BM cells and display an activated phenotype. Most intriguingly, these cells are concentrated into unique peri-vascular...
关键词: Esophageal cancer Radiotherapy Response Chemoradiotherapy Cancer stem cells DOI: 10.1593/neo.13464 被引量: 3 年份: 2013 收藏 引用 批量引用 报错 分享 全部来源 求助全文 EBSCO leaddiscovery.co.uk 相似文献 参考文献 引证文献Macrophage migration inhibitory factor (MIF) promotes cell survival by ...
Stem Cell Research & Therapy volume 15, Article number: 242 (2024) Cite this article 548 Accesses Metrics details Abstract Background Mesenchymal stromal cell (MSC)-derived exosomes (MSC-Exo) have been recognized for their significant role in regulating macrophage polarization, a process crucial to...
TAp63α mediates chemotherapeutic agent-induced apoptosis in human bone marrow mesenchymal stem cells. Human bone marrow-derived mesenchymal stem cells (MSCs) are currently widely used in cell therapy and tissue engineering. In vitro experiments have demonst... CC Lu - 《Stem Cells & Development》...
The CXCL12/CXCR4 axis is involved in homeostatic and inflammatory cell migration processes, including inflammatory and atherogenic T cell recruitment, stem cell homing, and cancer cell metastasis [12], [13]. G protein-coupled receptors regulate MAPK signalling pathways that result in the expression ...
This study will assess the safety and tolerability of milatuzumab (IMMU-115) when added to a standard regimen to prevent Graft vs. Host Disease (GVHD) in patients with hematologic malignancies undergoing stem cell transplant. 开始日期2013-12-01 ...