嵌合抗原受体T细胞(chimeric antigen receptor T cell,CAR-T)疗法目前已应用于血液肿瘤的治疗,前期研究发现CD74在白血病患者白血病干细胞中高表达,为了探索其对白血病细胞的杀伤作用,通过CD74 CAR表达载体的构建、慢病毒载体的包装及T细胞的感染,制备CD74 C...
thymic epithelial cells (TECs)Thymic epithelial cells (TECs) are indispensable for T cell development, T cell receptor (TCR) repertoire selection, and specific lineage differentiation. Medullary thymic epithelial cells (mTECs), which account for the majority of TECs in adults, are critical for ...
CD74别名:LN2, HLA-DR-associated invariant chain概述:II型膜蛋白信号定位:胞质、胞膜在病理学中的应用:不典型纤维黄色瘤(-)与恶性纤维组织细胞瘤(+)的鉴别。 B cell marker (not commonly used) 商品化试剂(排名不分先后,本网站对抗体质量不负责!)公司 克隆号 即用型(ml) 原液(ml) 基因科技 LN2 /...
cell surface forantigen presentationto T-cells[135]. Besides aiding peptide presentation, CD74 has been shown to function as a signaling molecule. By using mAbs against CD74 in was shown that a directsignaling pathwayinvolving nuclear factor-κB resulted in maturation of B-cells[136]. CD74 is...
is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant...
intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 相关产品 免疫组织化学 Secondary Antibodies 同型对照 IHC封片剂...
CD74 (HLA class II histocompatibility antigen gamma chain isoform b), is a transmembrane protein (on antigen presenting cells) which is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and...
Immune cell infiltration analysis Correlations between the copy number variation (CNV) of CD74 and the abundances of six types of tumor-infiltrating immune cells (TIICs) (B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells) were explored using the ...
Q4组患者还存在一些良好预后指标的增强,如CEBPA突变和t(8;21)。同时,根据AAML1031临床试验标准,Q4组患者被分为低危组的概率更大(Q4: low-risk: n=196, 82%, high-risk: 43, 18% vs. Q1-3: low-risk: 509, 72%, high-risk: 198, ...
2B). GO analysis via GSEA revealed that the genes coexpressed with CD74 were involved mainly in the cellular defense response, the adaptive immune response, T-cell activation, leukocyte cell-cell adhesion, the immune response-regulating signaling pathway, and the response to interferon-gamma (BP ...