嵌合抗原受体T细胞(chimeric antigen receptor T cell,CAR-T)疗法目前已应用于血液肿瘤的治疗,前期研究发现CD74在白血病患者白血病干细胞中高表达,为了探索其对白血病细胞的杀伤作用,通过CD74 CAR表达载体的构建、慢病毒载体的包装及T细胞的感染,制备CD74 C...
与其他三组相比,Q4组患者具有以下特征:中位年龄更大,外周血白细胞计数更低,更容易达到完全缓解(CR),但微小残留病变(MRD)率差异不大。Q4组患者还存在一些良好预后指标的增强,如CEBPA突变和t(8;21)。同时,根据AAML1031临床试验标准,Q4组患者被分为...
CD74别名:LN2, HLA-DR-associated invariant chain概述:II型膜蛋白信号定位:胞质、胞膜在病理学中的应用:不典型纤维黄色瘤(-)与恶性纤维组织细胞瘤(+)的鉴别。 B cell marker (not commonly used) 商品化试剂(排名不分先后,本网站对抗体质量不负责!)公司 克隆号 即用型(ml) 原液(ml) 基因科技 LN2 /...
T cellsTCREradication of tumors by the immune system relies on the efficient activation of a T-cell response. For many years, the main focus of cancer immunotherapy has been on cytotoxic CD8 T-cell. However, stimulation of CD4 helper T cells is critical for the promotion and maintenance of...
2、近年来,程序性细胞死亡蛋白1(programmed cell death protein 1,pd1)单克隆抗体等免疫检查点抑制剂在肝癌治疗中显示出较好的效果,但仅有一小部分病人对此免疫疗法产生有反应,随着靶向治疗和免疫治疗方法的逐渐成熟,研究者也发现了一些用于特定癌种的预测pd-1疗效的指标,如pd-l1表达水平、微卫星不稳(microsatellite...
intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 相关产品 免疫组织化学 Secondary Antibodies 同型对照 IHC封片剂...
CD74 is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. The cytoplasmic portion of CD74 can be released by intramembrane cleavage to activate NFkB. CD74 is upregulated in ...
近日,Science 杂志发表了一篇题为:MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses 的论文。 该研究发现的CD74是一种可同时对抗埃博拉病毒和SARS-CoV-2的细胞抗病毒蛋白的研究。鉴于不同病毒进入细胞相似的方式,提出寻找靶向抑制病毒进入细胞的抗病毒因子将成为...
CD74 (HLA class II histocompatibility antigen gamma chain isoform b), is a transmembrane protein (on antigen presenting cells) which is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and...
cell surface forantigen presentationto T-cells[135]. Besides aiding peptide presentation, CD74 has been shown to function as a signaling molecule. By using mAbs against CD74 in was shown that a directsignaling pathwayinvolving nuclear factor-κB resulted in maturation of B-cells[136]. CD74 is...