为了探究LSC静息、耐受化疗等干性特征的机制,本课题组前期研究发现CD74在静息的LSC中表达上调。正常生理状态下,CD74表达于MHC Ⅱ阳性细胞表面,包括树突状细胞(dendritic cell,DC)、单核细胞/巨噬细胞、朗格汉斯细胞等。此外,CD74也在多种恶性细胞中高表...
CD74 also regulates T-cell and B-cell developments, dendritic cell (DC) motility, macrophage inflammation, and thymic selection. The activation of receptor complex CD74/CD44 may lead to multiple intracellular signal pathways, such as the activation of the extracellular signal regulated kinase (ERK)...
CD74 exerts diverse biological functions in physiological and pathological situations, including T-cell and B-cell development, DC motility, macrophage inflammation, and thymic selection (Su et al. 2017). Our findings revealed that CD74 is an important factor in the differentiation of myeloid cells...
High CD74 expression is associated with the abundance of a variety of immune cell types, mediating interactions among tumor and immune cells and shaping the malignant behavior of HCC. In summary, CD74 may be a hallmark for determining the prognosis and immune cell infiltration levels of HCC pati...
Altogether, these studies strongly identify invariant chain as a master regulator of DC function, specifically coordinating the periodic modulation of cell movement and antigen uptake. How precisely CD74 mediates the periodic enrichment of myosin II at the front of the cell remains to be determined....
Tumour cell expressions of MIF and CD74 were observed in 95% and 98% of MPM specimens, respectively, with a homogenous distribution between the different histotypes. CD74 (Po0.001) but not MIF overexpression (P ¼ 0.231) emerged as an independent prognostic factor for prolonged OS. High ...
Aβ in the media and the cell lysates were measured using the ELISA kits for Aβ40 and Aβ42 (IBL 17713 and 17711, respectively). Equal amounts of total lysates and the cleared media were analyzed by Westerm blot. The measurement of stability of synthetic Aβ added to the media ...
//answers.microsoft.com/en-us/msoffice/forum/all/return-text-within-a-cell-based-on-other-text-in/3f9b9c31-afc6-43c9-91be-0c1aaf434c01 2020-05-19T16:12:08.0000000Z https://answers.microsoft.com/ja-jp/windows/forum/all/%e6%8b%a1%e5%bc%b5%e5%ad%90asf/423c1e73-4850-4505-8092-...
The relationship between weight loss, the systemic inflammatory response and quality of life in patients with inoperable non-small cell lung cancer (NSCLC)... HR Scott,DC Mcmillan,DJF Brown,... - 《Lung Cancer》 被引量: 219发表: 2003年 ...
We analyzed herein whether members of the tetraspanin superfamily are involved in human immature dendritic cell (DC) functions such as foreign antigen internalization, phagocytosis, and cell migration. We show that CD63, CD9, CD81, CD82, and CD151 are present in immature DCs. Whereas CD9 and...