CD4+T 细胞是高度多功能细胞,根据细胞因子环境、抗原呈递及共刺激分子表达的不同,可以分化成各种效应 Th 细胞:Th1、Th2、Th9、Th17、调节性T细胞(regulatory T cell,Treg)和T滤泡辅助(T follicular helper,Tfh)细胞等,它们产生并分泌...
当然,除了CD8+T细胞,其他T细胞亚型,比如CD4+T细胞以及其亚类调节性T细胞(regulatory T cells,简称Tregs)在TCC发生发展中的作用,以及对靶向PD-1的免疫治疗效果的影响,仍旧不得而知。 近日,来自美国加州大学的Chun Jimmie Ye和Lawrence Fong研究组在Cell杂志上发表题为Intratumoral CD4 T Cells Mediate Anti-tumor Cytot...
AlekseyV. Belikov. The role of reactive oxygen species and mitochondria in T-cellactivation. (图1) YoshihiroOhue,Hiroyoshi Nishikawa. Regulatory T (Treg) cells in cancer: Can Treg cellsbe a new therapeutic target? Cancer Sci. 2019 Jul;110(7):2080-2089.(图2) 作者:奇 诺 本文首发于“ 解...
细胞名称:调节性T细胞(Regulatory cell),简称Treg。Treg 细胞在免疫系统功能中扮演的是迷人又可爱的反派角色。 话说调节T细胞的发现,可追溯到1995年,彼时的日本生物学家坂口志文(Shimon Sakaguchi)教授发现成年小鼠的外周血中有一种特殊的 T细胞亚群——CD4+T 细胞亚群。若...
Immunology Regulatory T cells in CD4+ T cell-mediated autoimmune diseases| Contribution to the disease development and application in the disease prevention NORTHWESTERN UNIVERSITY Stephen D. Miller ZhangHongCD4T cells play a critical role in the maintenance of homeostasis through generating distinct ...
·CD4+ 调节性T 细胞:功能异质性、分群与疾病林瀚青 1 ,陶磊 1 ,路丽明 2(1.复旦大学附属眼耳鼻喉科医院 耳鼻咽喉科,上海 200031;2.上海市免疫学研究所,上海 200025 )摘要:传统观点认为, CD4+ 调节性 T细胞(regulatory Tcell,Treg )是1类能够感知免疫应答强弱并具有负向调控作用的细胞亚群,在机体免疫自...
[11]Xu L, Kitani A, Fuss I, et al. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol, 2007, 178(11): 6725-6729 [12]Wei G, Wei L, Zhu J, et al. Global mapping of ...
RegulatoryTcells(regulatory,t,cell,TR)canblocktheinflammatoryresponsetoautoantigensandlimitthedevelopmentofautoimmunediseases.Theseimmuneregulatorycellsexistintwoways:oneisnaturallyoccurringcellsinthebody,andtheotheristhecellsthatareinducedbytheinduction.Thisreviewfocusesonthemolecularmarkersandmechanismsofactionofcd4+...
Naturally occurring CD25(+)CD4(+) regulatory T cells are engaged in the maintenance of immunological self-tolerance and down-regulation of various immune r... H Yagi,T Nomura,K Nakamura,... - 《International Immunology》 被引量: 2398发表: 2004年 Cell Contact–Dependent Immunosuppression by Cd4...
调节性T细胞(Regulatory cells,Tregs ) 发挥免疫抑制作用的一类免疫细胞,避免免疫反应的过度发生,在肿瘤过程中常因其免疫抑制作用产生促瘤效果;其标记物为CD4+CD25+Foxp3+; CD4为辅助性T细胞(Helper T cell,TH )和调节性T细胞的通用标记物; CD25和Foxp3为调节性T细胞的特异标记物; ...