Regulatory T cells (Treg cells) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4 + CD25 + Treg cells, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been studied intensively because ...
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Reg... Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo ...
To address in vitro whether glucocorticoids plus beta(2)-agonists, compared with glucocorticoids alone, have greater inhibitory activity on CD4+ T cell responses to allergen, peripheral blood CD4+ T cell responses to allergen were compared in the presence or absence of the glucocorticoid fluticasone ...
CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB Kelsey B. Bennion Danya Liu Mandy L. Ford Nature Communications(2024) sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis ...
Interferon-γ couples CD8+ T cell avidity and differentiation during infection Lion F. K. Uhl Han Cai Audrey Gerard Nature Communications(2023) Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers ...
Methods, cells and vectors are provided for treating a subject for an autoimmune disease using stem cells transduced with genes encoding T cell receptors from IL-10 secreting regulatory T cells. The IL-10 secreting regulatory T cells are obtained from a donor of stem cells, the donor having be...
The regulatory regions needed for gene expression in general include a promoter region as well as the DNA sequences which, when transcribed into RNA, will signal the initiation of protein synthesis. Such regions will normally include those 5'-non-coding sequences involved with initiation of ...
Terasaki,T. Hanafusa 摘要: Accumulating lines of evidence have suggested that regulatory T cells (Tregs) play a central role in T cell-mediated immune response and the development of type 1A and fulminant type 1 diabetes. CD4+forkhead box protein 3 (FoxP3)+ T cells are composed of three ...
Treg purification was based on the negative selection of CD4 T cells isolated from spleen and liver of the iDC-vaccinated mice. Cell sorting was performed to obtain 98% pure CD49b+ or CD25+ Treg cells. Several doses of CD49b+ were intravenously (i.v.) injected at day 28 in ...
CD4(+)FOXP3(+) regulatory T cells are essential for immune tolerance, and murine studies suggest that their dysfunction can lead to type 1 diabetes (T1D). Human studies assessing regulatory T cell dysfunction in T1D have relied on analysis of FOXP3-expressing cell...