Resting regulatory CD4 T cells: A site of HIV persistence in patients on long-term effective antiretroviral therapy. PloS One. 2008; 3 :e3305.Tran, T. A., M. G. de Goer de Herve, H. Hendel-Chavez, B. Dembele, E. Le Nevot, K. Abbed, C. Pallier, C. Goujard, J. Gasnault, ...
Firstly, it seems possible that CD4+ T cells simply don't get a chance to stay in the resting state long enough to maintain a stable integrated pool, since SIV DNA is continuously driven to productive infection because of host cell PLoS Pathogens | www.plospathogens...
摘要: The latency of human immunodeficiency virus-type 1 (HIV-1) in resting primary CD4+ T-cells is the major barrier for viral eradication in patients on suppressive highly active antiretroviral therapy (HAART).Even with optimal HAART treatment...
These results suggest that the intracellular dNTP pools in resting CD4+ T-cells are rate limiting for HIV-1 reverse transcription, and SAMHD1 plays a regulatory role in this process. Furthermore, silencing SAMHD1 expression in post-activated resting CD4+ T-cells using specific siRNA or shRNA ...
(pDC) and B-cells did not induce latent infection in APC-T-cell co-cultures. We compared the RNA expression profiles of APC subpopulations that could and could not induce latency in non-proliferating CD4+T-cells. Gene expression analysis, comparing the CD1c+mDC, SLAN+DC and CD14+monocyte ...
Furthermore, presence of keratinocytes led to enhanced expression of the T regulatory cell-specific transcription factor Foxp3 in the CD4+CD25+ T-cell population which also showed regulatory function. Interestingly, the presence of the TLR9 ligand CpG was able to prevent the inhibition of T-cell ...
Resting and activated subpopulations of CD4+CD25+CD127loT regulatory cells (Treg) and CD4+CD25+CD127+ effector T cells in MS patients and in healthy individuals were compared. Peripheral blood mononuclear cells isolated using Ficoll Hypaque were stained
___ B cell→___ B, importante en la producción de anticuerpos. English-Spanish Medical Dictionary © Farlex 2012 lymphocyte nlinfocito;B (T, CD4, etc.) —linfocito B (T, CD4, etc.) English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, In...
Using RNA-seq and Illumina gene expres- sion microarrays, we also identified potential mediators of latent infection expressed by APC that could induce latency in the non-proliferating CD4+ T-cells during APC-T cell interactions. Results Monocytes are able to induce latency in resting CD4+ ...
During HIV infection, CD4+ T cells produce interleukin (IL) 2, upregulate FAS and other pro-apoptotic molecules, and change from an apoptosis-resistant state to a post-activation and apoptosis-prone state. However, the expression of apoptosis regulatory proteins such as BCL2 family members and ...